氧化铅与碘帕醇造影剂在离体胎盘血管CT三维重建中的显影效果比较  

A comparison on contrast agents between lead oxide and iopamidol using for CT three-dimensional ;reconstruction of blood vessels in isolated placenta

作　　者：许有江[1] 李从青[1] 许玲[2] 李欢[2] 张妤[1] 卫兵[1] 王文艳[1] 

机构地区：[1]安徽医科大学第二附属医院妇产科,合肥230601 [2]安徽医科大学第二附属医院放射科,合肥230601

出　　处：《中华解剖与临床杂志》2017年第1期1-5,共5页Chinese Journal of Anatomy and Clinics

基　　金：国家自然科学基金青年科学基金项目（81100412）;安徽省高校优秀青年人才支持计划（gxyqZD2016060）;中国博士后科学基金（2016M592038）;安徽省公益性研究联动计划项目（510111304041）

摘　　要：目的：探讨氧化铅与碘帕醇造影剂在离体胎盘血管CT 3D重建中的显影效果。方法选取2015年12月—2016年2月于安徽医科大学第二附属医院妇产科足月分娩、无妊娠合并症且产妇自愿放弃的离体胎盘20例进行前瞻性研究。采用简单随机化分组方法分为碘帕醇组和氧化铅组，每组10例。分别将氧化铅和碘帕醇造影剂混于自凝牙托材料进行胎盘动静脉血管灌注，然后行CT增强扫描及胎盘血管3D重建，对比观察两组胎盘血管3D重建显影效果，测量胎盘体积、血管容积及各级血管直径，组间采用独立样本t检验分析数据。结果成功构建18例胎盘血管造影标本，两组各有1例失败。氧化铅组的胎盘一级和二级血管饱满，立体感强，血管周围无明显伪影；但其三级和四级血管显影模糊，微血管及胎盘小叶显影稀疏。碘帕醇组的胎盘一级和二级血管显影不如氧化铅组饱满；但其三级和四级血管灌注完全，血管周围伪影少、显影清晰、走行自然，微血管及胎盘小叶显影均匀。氧化铅组与碘帕醇组的胎盘体积和胎盘血管容积比较，差异均无统计学意义（P值均〉0.05）；氧化铅组一、二级血管直径均大于碘帕醇组，而三、四级血管直径均小于碘帕醇组，差异均有统计学意义（P值均〈0.05）。结论氧化铅造影剂适用于一、二级胎盘血管造影，碘帕醇造影剂适用于三、四级胎盘血管造影。胎盘血管CT 3D重建后的定量测量方法可作为胎盘血管研究量化的基础。Objective To investigate the image for three-dimensional reconstruction of blood vessels in isolated placentas after using lead oxide or iopamidol as contrast agent. Methods A prospective study was conducted within 20 normal human placentas donated from puerperae without complications during pregnancy in the Second Hospital of Anhui Medical University from December 2015 to February 2016. The placentas were divided into two groups using simple random sampling and each group had ten placental samples. Lead oxide or iopamidol, mixed with colored self-curing denture base materials, was injected into both umbilical arteries and veins separately. Then CT scan was performed and post processing the images of placental blood vessels was completed using three-dimensional reconstruction technique. Placental volume, vascular volume and vessel diameters of different branches were measured using GE Adw 4. 4 software. independent samples t test was used to analyze the data. Results The images of the first and second grade vascular branches of the placentas using lead oxide as contrast agent were in the strong three-dimensional sense without obvious artifacts, while the third and fourth grade vascular branches in the images looked blurred, and the microvascular of the placental lobular in the images looked sparse. On the contrary, the first and second grade vascular branches of the placentas in the images using iopamidol as contrast agent had no so strong three-dimensional sense, while the third and fourth grade vascular branches’s perfusion had less peripheral vascular artifacts compared with the lead oxide group. The value of placental volume and vascular volume between the lead oxide and iopamidol groups had no significant differences （all P values〉0. 05）. The value of the diameter in the first and second grade vascular branches in the lead oxide group was significantly greater than that in the iopamidol group, while the value of the diameter in the third and fourth grade vascular branches was obviously smaller than t

关 键 词：胎盘 血管造影术 氧化铅 碘帕醇 成像 三维 造影剂 

分 类 号：R714[医药卫生—妇产科学] R816.91[医药卫生—临床医学]