雌激素、维生素D和骨形态发生蛋白质与骨质疏松症及心脑动脉钙化的发生机制  

The correlation and pathogenesis of estrogen, vitamin D and bone formation related protein in ;osteoporosis and cardiovascular, cerebrovascular artery calcification

作　　者：周锐[1] 许建中[1] 周华东[2] 

机构地区：[1]第三军医大学西南医院骨科,重庆400038 [2]第三军医大学大坪医院神经内科

出　　处：《中华解剖与临床杂志》2017年第1期83-86,共4页Chinese Journal of Anatomy and Clinics

摘　　要：目的：探讨雌激素、维生素D和骨形态发生蛋白质（ BMP）与骨质疏松症及心脑动脉钙化的相关性及其发病机制。方法在PubMed和中国知网中以雌激素、维生素D、BMP、骨质疏松和动脉钙化斑块为关键词检索1995年1月—2015年9月有关雌激素、维生素D缺乏和骨形成相关蛋白与骨质疏松、心脑动脉钙化斑块的关系等方面的相关文献，对骨质疏松与心脑动脉钙化斑块形成的相关性及发病机制进行分析总结。结果雌激素缺乏、维生素D缺乏均导致骨质疏松和心脑动脉钙化发生的风险增加。骨保护素、脂联素、BMP、骨桥蛋白等骨形成相关蛋白参与骨质疏松的形成而且是心脑动脉钙化发病的重要调控因子。结论雌激素、维生素D和骨形成相关蛋白与骨质疏松症及心脑动脉钙化的发生密切相关，并且可能有共同的病理生理机制；该理论对心脑血管疾病和骨质疏松的防治有重要作用。Objective To explore the correlation and pathogenesis of estrogen, vitamin D and bone formation related protein in osteoporosis, cardiovascular and cerebrovascular artery calcification. Methods Literatures about the relationship between estrogen, vitamin D deficiency and bone formation related protein and osteoporosis or vascular calcification plaque from January 1995 to September 2015 in PubMed and CNKI with the key words ＆quot; estrogen, vitamin D, bone formation related protein, osteoporosis and vascular calcification plaque＆quot; were selected. The correlation between osteoporosis and the formation of calcified plaque were analyzed and summarized. Results Both estrogen deficiency and vitamin D deficiency had close relationship with osteoporosis and vascular calcification plaque. Osteoprotegerin, adiponectin, bone morphogenetic protein and osteopontin were important cytokines for pathogenesis of osteoporosis associated with vascular calcification plaque. Conclusions Research on the pathogenesis of estrogen, vitamin D and bone formation related protein associated with osteoporosis, cardiovascular and cerebrovascular artery calcification is important for prevention and control of elderly chronic diseases like cardiovascular system diseases and osteoporosis.

关 键 词：骨质疏松 动脉钙化 细胞因子 雌激素 维生素D 

分 类 号：R580[医药卫生—内分泌]