骨桥蛋白在免疫相关性疾病中作用的分子机制新进展  

The progress of the molecular mechanism of osteopontin in immune-related diseases

作　　者：杨萍萍[1] 张微[1] 迟立君[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,150001

出　　处：《免疫学杂志》2017年第3期263-267,共5页Immunological Journal

摘　　要：骨桥蛋白(Osteopontin,OPN)是一种与免疫性疾病相关的多功能蛋白,是由被激活的巨噬细胞和淋巴细胞分泌的促炎细胞因子,在多种细胞中表达并通过与2种细胞黏附分子[整合素(α9β1、ανβ3、ανβ1、α4β1)和CD44]的结合而影响、调节许多生物学功能:包括免疫应答、组织重塑和血管增生。研究发现骨桥蛋白在炎症、癌症、细胞免疫和神经退行性疾病中明显升高。本文对骨桥蛋白在免疫相关性疾病中作用的分子机制作一概述,进而为OPN介导的相关疾病的治疗提供新的思路。Osteopontin（OPN） is a multifunctional protein associated with immune diseases and is a proinflammatory cytokine secreted by activated macrophages and lymphocytes. OPN is expressed in a variety of cells and affects the regulation of many biological functions（immune response, tissue remodeling and vascularization hyperplasia） by binding to two kinds of cell adhesion molecules： integrins（α9β1, ανβ3, ανβ1, α4β1） and CD44.Studies have shown that osteopontin is significantly elevated in inflammation, cancer, cellular immunity, and neurodegenerative diseases. This paper summarizes the molecular mechanisms underlying the role of osteopontin in immune-related diseases, and then provide new ideas for the treatment of OPN-mediated diseases.

关 键 词：骨桥蛋白 免疫相关性疾病 整合素 CD44 分子机制 

分 类 号：R593[医药卫生—内科学]