^(18)F-FDG-(OAc)_4在^(18)F-FDG中的残留及在小鼠体内的生物分布  

The ^(18)F-FDG-(OAc)_4 Residual in ^(18)F-FDG and its Bio-distribution in Mice

作　　者：王蕾[1] 张晓军[2] 周艳丽[1] 张锦明[2] 

机构地区：[1]包头市中心医院核医学科,内蒙古包头014040 [2]中国人民解放军总医院核医学科,北京100853

出　　处：《同位素》2017年第1期36-42,共7页Journal of Isotopes

摘　　要：为探讨^(18)F-FDG-(OAc)4在^(18)F-FDG中残留的原因及其与^(18)F-FDG在生物体内代谢分布的异同,本研究利用固相柱水解法制备^(18)F-FDG,研究NaOH用量、淋洗速率及淋洗液pH对^(18)F-FDG-(OAc)4残留的影响,以及^(18)F-FDG-(OAc)4在小鼠体内的代谢和分布规律。结果表明:NaOH不足是^(18)F-FDG-(OAc)4残留的主要原因,淋洗速率和淋洗液pH对其残留没有影响;注射^(18)F-FDG-(OAc)460min后,小鼠血、尿和脑代谢物中发现^(18)F-FDG-(OAc)4原形及部分水解物;小鼠体内分布结果显示,除肌肉外,^(18)F-FDG-(OAc)4和^(18)F-FDG在体内各脏器摄取值高低分布一致。To investigate the causes of ^18F-FDG-（OAc）4 residual in 18F-FDG and the discrepancy of bio-distributions between 18F-FDG-（OAc）4 and ^18F-FDG, 18F-FDG was prepared by hydrolysis on C-18 .The effect of NaOH dosage, elution rate, and eluent pH on ^18F-FDG-（OAc）4 residual ,the metabolism and biodistribution profiles of ^18F-FDG-（OAc）4 in mice were stutied. The results showed that insufficiency of NaOH was the main reason for ^18F-FDG-（OAc）4 residual, while the elution rate and the pH of the eluent posed no impact. After injecting 18F-FDG-（OAc）4 60 minutes, the partially hydrolyzed product and ^18F-FDG-（OAc）4 were found in metabolite of blood、urine and brain of the mice. The mice bio-distribution suggested that the uptake of 18F-FDG-（OAc）4 and 18F-FDG by organs followed the same pattern apart from muscle.

关 键 词：氟-18-脱氧葡萄糖 氟-18-四乙酰基脱氧葡萄糖 代谢 生物分布 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817.93[医药卫生—影像医学与核医学]