^(18)F-DOPA制备研究进展  

Research Progress in the Preparation of ^(18)F-DOPA

作　　者：贾丽娜[1,2,3] 张岚[1,2,3] 

机构地区：[1]中国科学院上海应用物理研究所放射化学与工程技术部,上海201800 [2]中国科学院钍基熔盐堆核能系统卓越创新中心,上海201800 [3]中国科学院核辐射与核能技术重点实验室,上海201800

出　　处：《同位素》2017年第1期71-77,共7页Journal of Isotopes

基　　金：国家自然科学基金(11505269)

摘　　要：6-[^(18)F]氟-L-多巴(^(18)F-DOPA)为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像。本文综述近几年亲电取代法和亲核取代法合成^(18)F-DOPA取得的新进展,重点介绍新型标记前体和手性相转移催化剂在亲核取代法制备^(18)F-DOPA中的应用。[^18F]6-fluoro-3,4-dihydroxy-L-phenylalanine（^18F-DOPA）has been known to be a useful radiotracer for neuropsychiatric diseases and brain malignancies,and it is also abundantly used for visualizing neuroendocrine tumors at present.However,its more widespread clinical use was hampered by the lack of a high specific activity,high yielding labeling method.This review mainly summarized new developments in the synthesis of ^18F-DOPA with electrophilic reactions and nucleophilic substitution reactions in recent years.Among these,considerable advances in nucleophilic synthesis had been achieved by developing novel precursors and utilizing chiral phase-transfer catalysts（cPTC）mediated fluorinations allowing for the production of ^18F-DOPA in high specific activity and high radiochemical yield.

关 键 词：^18F-DOPA 亲核取代 新型标记前体 手性相转移催化剂 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817.9[医药卫生—影像医学与核医学]