金属正电子核素^(64)Cu,^(68)Ga,^(86)Y和^(89)Zr的PET标记药物研究进展  

Positron Emission Radiometals ^(64)Cu,^(68)Ga,^(86)Y and ^(89)Zr Labeled PET Drugs

作　　者：陈文[1] 魏洪源[1] 周志军[1] 罗顺忠[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900

出　　处：《同位素》2017年第1期78-88,共11页Journal of Isotopes

摘　　要：^(64)Cu,^(68)Ga,^(86)Y和^(89)Zr具备不同的半衰期和特殊生物体内性质,丰富了PET药物的多样性,为疾病的诊断和治疗提供了新的契机。近年来,金属正电子核素^(64)Cu,^(68)Ga,^(86)Y和^(89)Zr标记的药物在正电子发射计算机断层显像(PET)诊断中的应用越来越多,^(64)Cu在乏氧显像中发挥重要作用,^(68)Ga在靶向神经内分泌(NET)类肿瘤的诊断药物领域发展迅速,^(86)Y,^(89)Zr有望在免疫PET和放射免疫治疗领域发挥作用。本文主要综述金属正电子核素^(64)Cu,^(68)Ga,^(86)Y,^(89)Zr的生产与纯化,溶液配位化学以及应用方面的研究进展。Positron emission radiometals ^64Cu,^68Ga,^86Y and ^89Zr have different half lives and special biological properties,not only enrich the diversity of PET drugs,but also provide a new opportunity for the diagnosis and treatment of disease.In recent years,positron emission radiometals ^64Cu,^68Ga,^86Y and ^89Zr have more and more applications in the medical diagnostics of PET（positron emission tomography）.^64Cu has already had a significant impact in cancer hypoxia imaging.^68Ga is developing rapidly in the field of diagnosis of NET（Neuroendocrine tumor）tumor.^89Zr and ^86Y are expected to play a role in the field of immunoPET and radioimmunotheray.This paper briefly reviews the research progress on the production and purification,solution coordination chemistry and applications of ^68Ga,^86Y,^89Zr and ^64Cu.

关 键 词：正电子发射计算机断层显像(PET) ^64Cu ^68Ga ^86Y ^89Zr 配位化学 临床应用 

分 类 号：R817.8[医药卫生—影像医学与核医学]