天然型调节性T细胞在胸腺内的分化发育机制  

The differentiation and development mechanism of natural regulatory T cells in the thymus

作　　者：汪瀚 翟原 

机构地区：[1]加州大学洛杉矶分校戴卫格芬医学院肝脏和胰腺移植外科,美国洛杉矶90095

出　　处：《南京医科大学学报（自然科学版）》2017年第1期15-19,共5页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：调节性T细胞(regulatory T cell,Treg)是一群胸腺来源的具有免疫抑制功能的T淋巴细胞,其与自身免疫疾病的发生、外周免疫耐受以及抗感染免疫、肿瘤免疫、移植免疫、变态反应等许多病理性免疫过程有着极其重要的关系。天然型调节性T细胞(natural Treg,n Treg)或称胸腺调节性T细胞(thymus regulatory T cell,t Treg)是调节性T细胞群中很重要的一个亚群。本文将对这一主要亚群及其分化、发育、增殖等过程和相关调控机制进行综述。Regulatory T cell（Treg） is a thymus-derived T lymphocyte lineage with the ability of immunosuppression in the periphery, and it plays a key role in autoimmune diseases, immune tolerance, immune system, tumor immunity, transplantation immunity, allergic reaction and many other pathological immune processes. Natural Treg cell （nTreg） or called thymus regulatory T cell （tTreg） is a very important T cell lineage in Treg ceils. In this paper,we make a review of this T cell lineage on the process of their differentiation, development and proliferation and the regulatory mechanism of them.

关 键 词：调节性T细胞 CD4+CD25+Foxp3+Treg 免疫抑制 分化发育 

分 类 号：R392.12[医药卫生—免疫学]