复方北冬虫夏草咀嚼片的制备  

Preparation of Compound Cordyceps Militaris chewable tablets

作　　者：苑广信[1] 张濛川 赵南晰[1] 安丽萍[1] 杜培革[1] 吕刚[2] 

机构地区：[1]北华大学药学院,吉林吉林132013 [2]北华大学生命科学研究中心,吉林吉林132013

出　　处：《时珍国医国药》2017年第1期113-115,共3页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省科技发展计划(No.2040311031YY);吉林省吉林市科技局项目(No.201464063)

摘　　要：目的优选西洋参总皂苷、枸杞黄芪多糖的提取工艺,并对咀嚼片的处方设计进行筛选,为工业化生产提供参考。方法以多糖得率为指标,采用L9(34)正交试验,通过考察料液比、提取时间、提取温度、提取次数确定枸杞黄芪多糖最佳提取工艺;以总皂苷得率为指标,采用L9(34)正交试验,通过考察乙醇浓度、提取液体积、提取时间、提取次数确定西洋参总皂苷提取最佳工艺;以咀嚼片外观、硬度、口感为指标优选咀嚼片的处方。结果枸杞黄芪多糖的最佳提取工艺为1:10料液比、100℃提取3次、每次3 h;西洋参总皂苷的最佳提取工艺为60%乙醇、10倍用量、提取3次、每次1 h;咀嚼片的最佳处方为:北冬虫夏草超微粉20%、西洋参总皂苷4.8%、枸杞黄芪多糖15%、β-环糊精10%、微晶纤维素14.2%、甘露醇20%、聚维酮k30 5%、果糖5%、硬脂酸镁4%、滑石粉2%。结论复方北冬虫夏草咀嚼片的提取工艺和处方设计合理,制备方法简单易行,适合工业化生产。Objective To optimize the extraction technology of total saponins and Lycium Barbarum-Astragalus Polysaccharides;research the formulation technology of chewable tablet; and provide a reference for industrial production. Methods Polysaccharide yield as the index,using L9（ 34） orthogonal test by examining the solid-liquid ratio,extraction time,extraction temperature,extraction times to determine the optimum extraction of Lycium Barbarum-Astragalus Polysaccharides; total saponins yield as the index,using L9（ 34） orthogonal test by examining the ethanol concentration,extract volume,extraction time,extraction times to determine the optimum extraction of total saponins of American ginseng; using chewable tablet’s color,tissue state,hardness,taste to determine the formulation design. Results The optimum extraction of Lycium Barbarum-Astragalus Polysaccharides is solid-liquid 1： 10,100℃ extracted for three times,3h for each time; the optimum extraction of total saponins of American ginseng is 10 times the amount of 60% ethanol,extracted for three times,1h for each time; the best prescription of chewable tablets：Cordyceps Militaris ultrafine under 20%,American ginseng total saponins 4. 8%,Lycium Barbarum-Astragalus Polysaccharides15%,β-cyclodextrin 10%,microcrystalline cellulose 14. 2%,mannitol 20%,povidone k 30 5%,fructose 5%,magnesium stearate 4%,talc 2%. Conclusion The extraction process and preparation of compound Cordyceps Militaris chewable tablets is reasonable,and the preparation method is simple and suitable for industrial production.

关 键 词：枸杞 黄芪 多糖 西洋参 总皂苷 咀嚼片 

分 类 号：R285.5[医药卫生—中药学]