僵蚕本草源流考证  

Herbal textual research on origin and development of Bombyx Batryticatus

作　　者：闻崇炜[1] 石莉[1] 赵烨清 欧阳臻[1] 詹志来 

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]中国中医科学院中药资源中心,北京100700

出　　处：《时珍国医国药》2017年第1期171-173,共3页Lishizhen Medicine and Materia Medica Research

基　　金：中央本级重大增减支项目(No.2060302);国家自然科学基金(No.81573529)

摘　　要：目的对僵蚕的基原、产地、功效及规格修治的药用历史沿革进行本草考证。方法查阅历代本草文献,并结合现代的研究文献。结果查清了基原、产地、功效及规格修治的源流变迁。结论考证出僵蚕基原最初为"食桑者,四月头番蚕,病风自死",目前也可人工用白僵菌感染家蚕4~5龄幼虫制得;考证出除文字记载的河南颖川外,山东棣州也应为僵蚕重要历史产区,当前主产区为江浙、安徽、四川、广东等地;僵蚕不仅有平肝息风、化痰散结的功效,还有望用于抗血栓、降糖降脂及抗肿瘤;规格等级最初要求为"色白、条直、质硬",后又增加了"断面光亮"及其它显微特征分析。上述结论有利于后续借助现代分子药学及药理学技术,更好地研究僵蚕的临床应用及质量监控,使其更好的造福人类。Objective To clarify the origin and development of Bombyx Batryticatus（ B. Batryticatus） with medicinal literatures.Methods Medicinal literatures of past dynasties were analyzed combined with modern references. Results The original source,producing area,clinical function and quanlity control of B. Batryticatus were summarized. Conclusion During the past dynasties,B. Batryticatus was obtained from the dried silkworm larvae,Bombyx mori Linnaeus,which are dead and stiffened due to the natural infection of Beauveria bassiana（ Bals.） Vuillant. Nowadays,It could be obtained from those dried silkworm larvae not only due to natural infection but also artificial infection of Beauveria bassiana（ Bals.） Vuillant. Historically,B. Batryticatus was mainly produced in Henan and Shandong. Nowadays,it could be produced mainly in Jiangsu,Zhejiang,Anhui,Sichuan and Guangdong. In traditonal Chinese medicine,B. Batryticatus was employed as analgesic and anticonvulsant to subdue diverse symptoms such as headaches,toothaches,vertigo,scrofula,tonsillitis,and convulsions caused by the endogenous wind in ancient time. Currently,it could be worked as anticoagulation,hypolipidemic and antitumor drug,and used to treat Bell’s palsy,asthma,and thyroid adenoma. Usually,those white,straight,thick,and hard B. Batryticatus were considered better. These conclusions were be helpful for further study of clinical usage and quality control of B. Batryticatus by means of morden molecular biology and pharmacology technology.

关 键 词：僵蚕 基原 产地 功效 规格修治 

分 类 号：R281.3[医药卫生—中药学]