铜催化α,β-不饱和酯的环外碳碳双键非对称还原反应  

Cu-catalyzed asymmetric reduction ofα,β-unsaturated carboxylic acid esters

作　　者：赵四娥 陆蒋璐 韩忠飞 芮苗 郝鑫[1] Shagufta Parveen 朱长进[1] 

机构地区：[1]北京理工大学化学与化工学院学院,北京100081

出　　处：《中国科技论文》2016年第24期2791-2796,共6页China Sciencepaper

基　　金：高等学校博士学科点专项科研基金资助项目(20111101110042)

摘　　要：含手性配位体的铜氢化合物在非对称还原反应中是1种重要的催化剂。为了进一步确定该铜催化体系对α,β-不饱和酯化合物适用范围,筛选配体,优化反应条件,进行了环外烯烃的烯烃还原反应,结果表明含手性配位体的铜氢催化体系能令α,β-不饱和酯的环外碳碳双键非对称还原反应得到较高的产率,对映体的产率可提高至95%,对映体过量值可提高至89%。Copper hydride complexes with chiral ligands are important catalysts in asymmetric reductions.In order to further determine the application scope of the copper catalyst system to theα,β-unsaturated esters,on the basis of recent studies,we screened the ligands and optimized the reaction conditions to carry out the olefins reduction reaction of the exocyclic olefins.The results show that a series of exocyclic olefins could be reduced with good to excellent yields and the enantioselectivities are up to95% and 89% enantiomeric excess.

关 键 词：Α Β-不饱和酯 2-双(二-对甲苯基膦)-1 1-联萘 铜 

分 类 号：O621.251[理学—有机化学]