方刺参酒补肾壮阳作用的实验研究  

The Experimental Research of Fangcishen Wine on Pharmacological Activities of Tonifying the kidney and Invigorating Yang

作　　者：阮氏锦秀 廖遥灵 罗俊[1] 杨斌[1] 

机构地区：[1]广西医科大学药学院,广西南宁530021

出　　处：《广西中医药大学学报》2016年第4期5-8,共4页Journal of Guangxi University Of Chinese Medicine

摘　　要：[目的]观察方刺参酒的补肾壮阳作用,为其应用和开发提供科学实验依据。[方法]1取SPF级SD雄性大鼠60只,去势3 d后将其随机分为6组:模型对照组,溶媒对照组,阳性对照组,方刺参酒高、中、低剂量组,每组10只;另取10只不去势不做任何处理作为正常对照组。每组连续给药21 d,第21 d给药1 h后,将YLS-9A生理、药理电子刺激仪的刺激电极置于大鼠阴茎部位,观察大鼠阴茎勃起功能及对附性器官脏器指数的影响;2取SPF级SD雄性大鼠60只,随机分成6组:正常对照组,阳性对照组,溶媒对照组,方刺参酒高、中、低剂量组,每组10只,每日给药1次,连续28 d。于末次给药1 h后,进行交配实验,记录雄性大鼠扑捉潜伏期、扑捉次数、射精潜伏期及射精次数。[结果]去势后的大鼠包皮腺、精囊腺+前列腺、提肛肌的脏器指数均显著降低,垂体、肾上腺、胸腺等脏器指数显著提高,与正常对照组比较差异显著(P<0.05或P<0.01),但方刺参酒无明显促进这些器官发育的作用;与模型对照组比较,方刺参酒高、中剂量组可显著缩短大鼠阴茎勃起潜伏期(P<0.05或P<0.01);与正常对照组比较,方刺参酒中、低剂量组可明显缩短扑捉潜伏期和射精潜伏期(P<0.05),明显增加射精次数(P<0.05或P<0.01)。[结论]方刺参酒可明显提高生殖反射阈值及兴奋水平,具有一定的补肾壮阳作用。[ Objective ] To study the pharmacological activities of Fangcishen wine for tonifying the kidney and Yang so as to provide scientific experimental basis for its application and development. [Methods]① SPF-SD male rats were castrated 3 days later and then were randomly divided into 6 groups： model group, solvent group, positive control group and Fangcishen wine groups in high, medium and low doses with 10 rats for each group. The other 10 rats without any treatment for castration were taken as he con- trol group. Each group was administered a continuous treatment for twenty-one days. After one hour of administration on the twenty- first day, the stimulating electrodes of physiological and pharmacological electronic-stimulation-instrument named YLS-9A were placed at the rat penises to observe the erectile function of rats and the influence of the accessory sex organ index; ②SPF-SD male rats were randomly divided into 6 groups： control group, positive control group, solvent group and Fangcishen wine groups in high, medium and low doses with 10 rats for each group. Each group was administered 1 times daily for 28 consecutive days. After one hour of the last administration, the mating experiment was conducted to record the latent period, the number of capture, the latency of e- jaculation and the frequency of ejaculation. [ Results] The index of visceral gland, seminal vesicle, prostate and levator ani muscle were significantly decreased in castrated rats, and the indexes of pituitary, adrenal gland and thymus were significantly increased compared with those of control group （P〈0.05 or P〈0.01 ）. Fangcishen wine had no significant role in promoting the development of these organs. The high-dose and the medium- dose of Fangcishen wine groups can significantly shorten the rat penis erection latency compared with those of model group （P〈0.05 or P〈0.01 ）. The medium-dose and the low-dose of Fangcishen wine groups can signifi- cantly shorten the capturing latency and ejaculation latency （P〈0.05�

关 键 词：方刺参酒 补肾壮阳 交配试验 实验研究 

分 类 号：R285.5[医药卫生—中药学]