壳聚糖的敏化辐射降解  

Irradiation and sensitizing effects on chitosan degradation

作　　者：李兆龙 汪瑛琦 谢裕颖 陆鹏[2] 章月红 王校常[2] 刘亚建 

机构地区：[1]浙江省能源与核技术应用研究院,杭州310012 [2]浙江大学,杭州310058

出　　处：《辐射研究与辐射工艺学报》2017年第1期35-41,共7页Journal of Radiation Research and Radiation Processing

基　　金：浙江省科技计划与高校;企业合作研发开发项目(2014F60003)资助~~

摘　　要：采用电子束辐照与敏化剂协同降解粉体壳聚糖,以制备具有良好生物活性的低分子量粉体壳聚糖。使用凝胶渗透色谱仪对壳聚糖的分子量进行测定;通过傅里叶变换红外光谱和X-射线衍射仪分别对降解后壳聚糖的化学性能包括主链结构和结晶度进行表征。实验结果表明,降解后的壳聚糖主链结构无明显变化,结晶度随分子量的减小而增大;在敏化剂存在的条件下,较低的吸收剂量(20 kGy)即可有效地降解粉体壳聚糖,得到数均分子量(M_n)为1 170的低分子量产物,且降解速率增大至1.51×10^(-5)。Interaction systems of electron beam irradiation and sensitizers were used to degrade wet chitosan powder for preparing chitosan with low molecular weight and well biological activity. The degraded molecular weight of the sample was characterized by gel permeation chromatography（GPC）, and chemical characteristics including main chain structure and crystallization were determined by Fourier transform infrared spectroscopy（FTIR） and X ray diffraction（XRD）, respectively. The experimental results showed that no obvious change generates in the main chain structure of the degraded chitosan, and the crystallization increased with the decreasing molecular weight. With the presence of sensitizers, the degraded molecular chitosan can be decreased from 1.1×105 to 1 170 at low absorbed dose of 20 k Gy with higher rates of 1.51×10-5.

关 键 词：壳聚糖 辐射降解 敏化剂 分子量 

分 类 号：TL13[核科学技术—核能科学]