保定市COXA6型手足口病伴脱甲症病例流行病学特征及相关因素分析  

Epidemiological characteristics and correlative factors of hand-foot-mouth disease with onychomadesis caused by COXA6,Baoding

作　　者：李娟娟[1] 王玉肖[2] 周美静[1] 赵灿[3] 苏明[1] 陈妍[1] 郑丽伟[1] 王辉[1] 张亮[1] 倪祥文[1] 

机构地区：[1]保定市疾病预防控制中心,河北保定071000 [2]唐县人民医院,河北唐县072350 [3]保定市第一中医院,河北保定071000

出　　处：《现代预防医学》2017年第5期778-781,共4页Modern Preventive Medicine

基　　金：保定市科学技术研究与发展指导计划项目;项目编号为15ZF088

摘　　要：目的了解保定市COXA6型手足口病伴脱甲症病例的流行病学特征及相关因素,为制定防控措施提供科学依据。方法采用荧光定量RT-PCR法对2015年1月至2016年5月保定市哨点医院采集的手足口病病例咽拭子标本进行柯萨奇病毒A6型核酸检测,筛选COXA6型手足口病,并按是否伴有脱甲分为脱甲组和未脱甲组,利用检验对两组人群分布、临床特征、皮损特征及卫生行为情况进行对比分析,并利用Logistic回归分析COXA6型手足口病伴脱甲症的相关因素。结果保定市COXA6型手足口病伴脱甲症病例主要集中在5岁以内,以1~2岁患儿所占比例最高且男性多于女性。既往有皮肤过敏史(OR=5.230)、皮疹在指或趾甲周围分布(OR=10.599)和皮疹面积大于5%(OR=10.776)为COXA6型手足口病伴脱甲症病例的危险因素。结论对于既往有皮肤过敏史、皮疹在指或趾甲周围分布以及皮疹面积大于5%的COXA6型手足口病患儿要加强重视,以防其脱甲症的发生。同时在COXA6型手足口病流行期间加强的卫生防范措施,不会导致脱甲症的发生。Objective To recognize the epidemiology and correlative factors of hand-foot-mouth disease（ HFMD） with onychomadesis caused by COXA6 in Baoding city,and to provide a scientific basis for making prevention and control measures.Methods the throat swab specimens of HFMD were collected from surveillance hospital of Baoding city during January 2015 to May 2016 for nucleic acid detection of coxsackievirus 6（ COXA6） by fluorescent quantitation RT-PCR. The COXA6 positive cases were divided into onychomadesis group and non-onychomadesis group. the test was used for comparative analysis of population distribution,clinical manifestation,skin lesion features and health habits between onychomadesis and non-onychomadesis groups. The correlative factors of COXA6 positive HFMD with onychomadesis were explored by Logistic regression. Results Onychomadesis cases focus on the group below 5 years old children suffered COXA6 positive HFMD and the proportion of 1 to 2 years old children group were the highest. The proportion of male was higher than female. The risk factors of onychomadesis were the previous history of skin allergies（ OR = 5. 230）,exanthem around nails of fingers or toes（ OR= 10. 599） and exanthem involving above 5% of the body surface area（ OR = 10. 776）. Conclusion Emphasis should be paid on the COXA6 positive HFMD cases with the previous history of skin allergies,exanthem around nails of fingers or toes and exanthem involving above 5% of the body surface area,in case of the occurrence of onychomadesis,and at the same time we should strengthen health care during the COXA6 epidemic in case of the occurrence of onychomadesis.

关 键 词：柯萨奇肠道病毒A6 手足口病 脱甲症 相关因素 流行病学 

分 类 号：R181.23[医药卫生—流行病学]