金叶败毒颗粒辅助治疗烧伤脓毒症的临床效果研究  

Clinical effect of Jinyebaidu Granule on the treatment of severe burn sepsis

作　　者：郑伟才[1] 于爱香[1] 

机构地区：[1]河南科技大学第一附属医院,洛阳471003

出　　处：《中药药理与临床》2016年第6期190-192,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察金叶败毒颗粒佐治烧伤脓毒症的临床效果。方法:选取2013年2月至2014年2月我科室收治的烧伤并发脓毒症患者45例,按随机双盲法将其分为对照组22例和观察组23例。对照组给予常规治疗,观察组在对照组基础上加用金叶败毒颗粒。记录并分析治疗前和治疗后10天两组患者体温、心率、白细胞、中性粒细胞、血尿素氮、血肌酐、肿瘤坏死因子(TNF-α)和白细胞介素-8(IL-8)的水平变化情况。结果:治疗后观察组患者体温、心率分别为(37.2±0.4℃、85.5±5.1次/分),均明显低于对照组(38.2±0.6℃、103.8±7.5次/分);观察组治疗后白细胞和中性粒细胞分别为(7.96±2.34×109/L、55.76±5.83%),均明显低于对照组(14.28±3.61×109/L、69.46±7.15%);3观察组治疗后血尿素氮和血肌酐分别为(7.4±0.6mmol/L、90.1±2.2μmol/L),均明显低于对照组(9.2±1.0mmol/L、95.7±3.3μmol/L);4观察组治疗后TNF-α和IL-8分别为(3.15±0.71ng/ml、3.01±0.42ng/ml),均明显低于对照组(5.01±0.83ng/ml、4.19±0.53ng/ml)。结论:金叶败毒颗粒可调节烧伤脓毒症患者的体温和心率,维护肾脏功能,降低患者体内炎症水平。Objective： To observe the clinical effect of Jinyebaidu Granule on the treatment of severe burn sepsis. Methods： 45 patients with sepsis, from February 2013 to February 2014, were randomized double-blindly divided into 22 cases in the control group and the observation group of 23 cases. The control group received conventional treatment, observation group were based on the use of traditional Chinese medicine Jinyebaidu. Recorded and analyzed before treatment and after 10 days the two groups of patients body temperature, heart rate, white blood cells, neutrophils, blood urea nitrogen, creatinine, tumor necrosis factor （TNF-α） and interleukin -8 （IL-8） changes in level. Results： After treatment, the observation group were body temperature, heart rate was （ 37.2 ± 0.4℃, 85.5 ± 5.1 beats / min）, were lower than the control group （38.2 ± 0.6 ℃, 103.8 ± 7.5 beats / min）, and the difference was significant （P 〈 0.05 ） ; the observation group after treatment leukocytes and nentrophils were （7.96 ± 2.34 ×10^9/L, 55.76 ± 5.83% ）, were lower than the control group （ 14.28 ± 3.61 × 10^9/L, 69.46 ± 7.15 % ）, and the differences were statistically significant （ P 〈 0.05） ; ③after treatment, blood urea nitrogen and serum creatinine observation group were （7.4 ± 0.6mmol/L, 90.1 ± 2.2μmol/L） , They were lower than the control group （9.2 ± 1. 0mmol/L, 95.7 ± 3.3μmol/L） , and the differences were statistically significant （ P 〈 0.05 ） ; TNF-α and IL-8 were （3.15 ± ④ after observation group 0.71ng/ml, 3.01 ± 0.42ng/ml） , were lower than the control group （5.01 ± 0.83ng / ml, 4.19 ± 0.53ng/ml）, and the differences were statistically significant （ P 〈 0.05）. Conclusion： Jinyebaidu can adjust temperature and heart rate of severe burn sepsis patient, maintain kidney function, reduce inflammation in the patient＇s body. it is a safe and effective treatment, and be worthy of clinical applicatlon

关 键 词：金叶败毒颗粒 脓毒症 炎症因子 肾脏功能 

分 类 号：R644[医药卫生—外科学] R459.7[医药卫生—临床医学]