钒化合物药用研究前景展望  

Promise and prospects of vanadium compounds in medicinal research

作　　者：杨晓改[1] 李逸[1] 刘会雪[1] 卞卫霞 洪艺华 

机构地区：[1]北京大学药学院化学生物学系,北京100191

出　　处：《中国科学：化学》2017年第2期144-154,共11页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21171011;21671009)资助项目

摘　　要：本文针对钒化合物在药用研究中的挑战,结合国内外在相关领域的主要进展,从其作用机制的化学基础出发,分析了钒化合物可能的作用物种以及钒化合物所诱导产生的活性氧物种在其生物效应中的作用;同时,从疾病之间的相互联系,探讨了如何有效利用钒化合物生物效应的特点,并进一步指出钒化合物在药用研究中的前景及未来的研究策略.Considering the challenges to vanadium compounds in medicinal research,and based on the latest advances in the related fields,the possible working species and the role of the induced generation of reactive oxygen species in their biological effects were examined on the chemical basis underlying the mechanism of vanadium compounds.The issue of how to take advantage of diverse biological effects of vanadium compounds was explored in terms of the correlation between various diseases.Furthermore,the promise and prospects of vanadium compound in medicine were also indicated.

关 键 词：钒化合物 胰岛素信号通路 活性氧物种 糖尿病 肿瘤 阿尔茨海默症 

分 类 号：R96[医药卫生—药理学]