8-羟基喹啉及其衍生物金属配合物抗肿瘤和抗菌活性研究进展  

Progress on antitumor and antibacterial activity of 8-hydroxyquinoline and its derivatives' metal complexes

作　　者：覃姣兰 曹倩倩[1] 覃其品[1] 梁宏[1] 陈振锋[1] 

机构地区：[1]省部共建药用资源化学与分子工程国家重点实验室,广西师范大学化学与药学学院,桂林541004 [2]广西百色职业学院,百色533000

出　　处：《中国科学：化学》2017年第2期172-182,共11页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21431001,81473102,21271051);教育部创新团队(IRT_16R15);广西“八桂学者”项目;广西自然科学基金创新团队项目(2016GXNSFGA380005)资助

摘　　要：铂类抗癌药物在临床上的成功应用,极大推动了金属药物化学的发展.寻找新型作用机制金属药物已成为药物化学研究领域的热点之一.本文就8-羟基喹啉及其衍生物金属配合物在抗肿瘤和抗菌方面的研究进展进行综述,从金属配合物的合成、结构、活性、作用机制、构效关系等总结了8-羟基喹啉及其衍生物金属抗肿瘤配合物的最新研究进展.对8-羟基喹啉及其衍生物金属抗菌配合物的研究也进行了总结,从中发现了一些活性基团及卤代效应的趋势,为设计和开发具有应用前景的8-羟基喹啉及其衍生物金属抗肿瘤、抗菌药物提供了重要的参考.Platinum-based anticancer drugs have been successfully applied in clinical,which greatly promoted the development of metal-based medicinal chemistry.Currently,seeking for metal-based drugs with new action mechanism has become one of the hot topics in medicinal chemistry.Herein,we review the research progress on antitumor and antibacterial activity of 8-hydroxyquinoline and its derivatives＇ metal complexes.From synthesis,structure,activity,action mechanism and structure-activity relationship,the recent progress of 8-hydroxyquinoline and its derivatives＇ metal complexes with antitumor activity have been summarized.Also,the advances of 8-hydroxyquinoline and its derivatives＇ antibacterial metal complexes have been reviewed.Basing the facts mentioned-above,we find some active groups and some trends of halo-substituted effect,which may afford important references for designing and developing new antitumor and antibacterial 8-hydroxyquinoline and its derivatives＇ metal-based drugs.

关 键 词：8-羟基喹啉 衍生物 金属配合物 抗肿瘤 抗菌 

分 类 号：O641.4[理学—物理化学]