盐酸替罗非班对急性心肌梗死直接 PCI 术无/慢复流患者疗效分析  

Gffect of tirofiban hydrochloride on no/slow-reflow in acute myocardial infarction patients with PCI

作　　者：李玉敏[1] 

机构地区：[1]南阳医学高等专科学校第二附属医院内二科,河南南阳473000

出　　处：《中国实用医刊》2017年第2期4-6,共3页Chinese Journal of Practical Medicine

摘　　要：目的：研究分析盐酸替罗非班对急性心肌梗死直接经皮腔内冠状动脉介入治疗（PCI）无/慢复流患者的临床效果。方法选择2013年5月至2015年5月急性心肌梗死直接 PCI 术无/慢复流患者54例，随机分为两组，每组27例。对照组采用常规治疗，观察组采用盐酸替罗非班治疗，对比两组疗效。结果观察组直接 PCI术后血流情况显著优于对照组，差异有统计学意义（ P 〈0.05）；观察组肌钙蛋白（ cTnI）和肌酸激酶同工酶（CK-MB）峰值水平、平均水平显著低于对照组，差异有统计学意义（P 〈0.05），且两组患者术后均未出现心血管事件和出血。结论盐酸替罗非班治疗急性心肌梗死直接 PCI 术后无/慢复流患者能够显著降低 cTnI 和 CK-MB 峰值水平、平均水平，值得推广。Objective To analyze the clinical effect of tirofiban hydrochloride on no / slow reflow in patients with acute myocardial infarction who underwent percutaneous coronary intervention（ PCI）. Methods From May 2013 to May 2015,54 patients with acute myocardial infarction treated with PCI with no / slow-reflow were randomly divided into two groups,with 27 cases in each group. Control group received conventional treatment,and observation group received tirofiban hydrochloride treatment. The effects between the two groups were compared. Results The blood flow after PCI in observation group was significantly better than that in the control group,the difference was significant（P 〈 0. 05）. The peak and average value of cTnI and CK-MB in observation group were significantly lower than those in the control group,the differences were significant（P 〈0. 05）,and there was no postoperative cardiac event or bleeding. Conclusions Tirofiban hydrochloride in treatment of acute myocardial infarction after direct PCI no / slow-reflow can significantly reduce the peak and average value of cTnI and CK-MB,it is worthy of promotion.

关 键 词：盐酸替罗非班 急性心肌梗死 经皮冠状动脉介入治疗术 无/ 慢复流 

分 类 号：R542.22[医药卫生—心血管疾病]