消退素 D1、白细胞介素-6在急性心肌梗死及再灌注患者中的表达  

Gxpression of resolvin D1 and interleukin-6 in the patients with acute myocardial infarction and reperfusion

作　　者：高莉[1] 朱宗涛[1] 朱曙光[1] 马运祥[1] 

机构地区：[1]山东省滕州市中心人民医院心内三科,277500

出　　处：《中国实用医刊》2017年第2期6-9,共4页Chinese Journal of Practical Medicine

摘　　要：目的：研究消退素 D1（RvD1）及白细胞介素-6（IL-6）在急性心肌梗死及急诊经皮冠状动脉介入治疗（PCI）术后心肌缺血再灌注患者中的表达及相关性，探讨其在急性心肌梗死发生发展中和急诊 PCI 术后心肌缺血再灌注中可能的作用及机制。方法采用酶联免疫吸附法（ELISA）检测30例对照组及30例心肌梗死患者血清中 RvD1、IL-6含量。30例心肌梗死患者均行急诊 PCI，检测患者 PCI 术后2、4、12、24 h 血清中 RvD1、IL-6含量。对血浆 RvD1、IL-6含量进行相关性分析。结果心肌梗死患者及急诊 PCI 术后 RvD1、IL-6含量明显高于对照组（P 〈0.01）。急性心肌梗死患者中，与 PCI 术前比较，PCI 术后2 h 血浆 RvD1、IL-6含量明显升高，PCI 术后4 h 血浆RvD1、IL-6含量达到最高值（P 〈0.01），至 PCI 术后24 h 血浆 RvD1、IL-6含量基本恢复到术前水平。相关性分析显示，血浆 RvD1水平与 IL-6水平呈正相关（P 〈0.01）。结论 RvD1作为一种新型抗炎介质在急性心肌梗死及PCI 术后心肌缺血再灌注发病机制中可能起到重要的作用。Objective To investigate the expression and correlation of RvD1 and IL-6 in patients with acute myocardial infarction and reperfusion and its effect on the pathogenesis of acute myocardial in-farction and reperfusion. Methods The levels of RvD1 and IL-6 were detected in 30 cases of acute myo-cardial infarction and 30 cases of normal control group by enzyme linked immunosor-bent assay（ELISA）. The 30 patients with acute myocardial infarction received percutaneous coronary intervention（PCI）within 6 hours from admittion. The levels of RvD1 and IL-6 were detected at the time of 2,4,12,24 hours af-ter operations. The correlation of RvD1 with IL-6 was analyzed. Results The levels of RvD1 and IL-6 in patients with acute myocardial infarction and after PCI were significantly higher than those in normal group（P 〈 0. 01）. In the patients with AMI,compared with before PCI,the levels of RvD1 and IL-6 had increased significantly after 2 hours of PCI（P 〈 0. 01）,then reached the maximum after 4 hours of PCI （P 〈 0. 01）,and reduced to the level of pre-operation after 24 hours of PCI. Correlation analysis showed that the level of RvD1 was positively correlated with IL-6. Conclusions RvD1 may play an important role in the pathogenesis of acute myocardial infarction and reperfusion.

关 键 词：消退素 D1 白细胞介素-6 急性心肌梗死 心肌缺血再灌注 经皮冠状动脉介入治疗 

分 类 号：R542.22[医药卫生—心血管疾病]