精准医学与中医药现代化研究——五论创建新医药学  

Precision Medicine and Modernization Research on Traditional Chinese Medicine——The Fifth Discussion on the Proposal of Holistic Systems Medicine

作　　者：罗国安[1] 谢媛媛[1] 王义明[1] 范雪梅[1] 梁琼麟[1] 

机构地区：[1]清华大学/教育部中医药现代化网上合作研究中心,北京100084

出　　处：《世界科学技术-中医药现代化》2017年第1期19-29,共11页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委重点项目(81130066):基于整体观的中药复方现代化基础研究;负责人:罗国安;国家自然科学基金委重点项目(81230079):细胞膜色谱技术用于安全性和有效性评价的基础研究;负责人:王义明;国家自然科学基金委面上项目(81473174):基于整合生物标志物体系的补肾中药延缓衰老作用基础研究;负责人:谢媛媛;中国人民解放军1226重大专项(AWS16J018);负责人:罗国安

摘　　要：本文阐述了精准医学的由来,指出了精准医学的优势和现阶段的不足。以中药复方"糖肾方"的现代研究为例,介绍了中医药理论指导下的中医药精准医学研究。针对目前中医药现代化研究中存在的"方-病-证割裂"和"基因-蛋白质-代谢物分离"两大问题,提出了建立"药物系统-生物系统"模式的关键科学问题和实现"方-病-证整合"研究途径的解决之道,给出了研究路线总体设计的框架。介绍了"方-病关联研究"、"病-证结合研究"和"方-病-证整合研究"三阶段的具体方法和相应研究结果,并进行了小结。提出了精准医学是现代医学发展的一个里程碑。在中医药面临创新性突破发展之际,精准医学将推动中医药现代化研究,也将为创建新医药学提供新的推力。The origin of precision medicine was discussed in this article, as well as its advantages and deficiencies at this stage. ＂Tangshen formula＂ was taken as an example to explain a rational and ideal mode of traditional Chinese medical（TCM） precision medicine research under the guidance of TCM theory. In view of the two major problems existing in the TCM modernization research, including the separated strategy among ＂formula-disease-syndrome＂ and independent research approach using genomics, proteomics and metabonomics, critical scientific issues on developing the ＂drug system to biological system＂ research mode and solutions for integrating ＂formula-disease-syndrome＂ were proposed here, and the roadmap and total framework of top design were also provided. The specific methods and the corresponding research results on ＂Tangshen formula＂ at the three stages concluded as ＂formula-disease related＂, ＂disease-syndrome combinated＂ and ＂formula-disease-syndrome integrated＂ were introduced and summarized. At this time for the innovative breakthrough development of TCM, precision medicine will promote the TCM modernization research, and also will provide a powerful driving force for the establishment of holistic systems medicine.

关 键 词：精准医学 新医药学 中医药现代化研究 “药物系统-生物系统”模式 “方-病-证”整合研究 

分 类 号：R2-03[医药卫生—中医学]