糖脂代谢病与精准医学  

Glucolipid Metabolic Disease and Precision Medicine

作　　者：郭姣[1] 肖雪[1] 荣向路[1] 叶得伟[1] 严诗楷[1] 

机构地区：[1]广东药科大学广东省代谢病中西医结合研究中心,广州510006

出　　处：《世界科学技术-中医药现代化》2017年第1期50-54,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委重点项目(81530102):调肝启枢化浊法防治糖尿病冠心病效应特点及机制研究;负责人:郭姣

摘　　要：糖脂代谢紊乱性疾病的发病机制复杂,临床上往往多病并发,单病种治疗模式疗效亟须提升。基于大量临床实践以及理论与基础研究,遵循中西医结合研究模式,笔者综合分析了高脂血症、脂肪肝、糖尿病、高血压病、动脉粥样硬化性心脑血管病等系列糖脂代谢紊乱性疾病的核心病机和病理,整体把握了疾病本质及其共性特征,提出"糖脂代谢病(Glucolipid Metabolic Disease,GLMD)"概念和"枢纽肝代谢稳态调节系统"理论,创立以"调肝启枢化浊法"为代表的综合一体化防控策略和方法。GLMD的理论与研究方法与精准医学的研究思路有相同之处,同时又独具特色。本文探讨了GLMD的部分研究内容以及实现该复杂疾病精准诊疗的思路和方法,并在此基础上对GLMD的精准医学未来研究工作的重要方向和难点问题进行了深度解析与展望。Diseases of glucose and lipid metabolism disorder, presented rather complicated pathological mechanism, often with clinical pattern of multiple concurrent diseases. Therefore, the traditional single-disease based on treatment methods need improving. In view of plenty of clinical practice, theatrical and fundamental researches, the pathological mechanisms of some chronic disorders, such as hyperlipidemia, nonalcoholic fatty liver disease, type 2 diabetes, hypertension, atherosclerosis and severe cardiovascular complications, resulted from the impairment in the metabolism of glucose and lipid were investigated using the method of integrated Chinese and western medicine. Overall, the features of these diseases and their common characteristics were discovered, and accordingly we defined the new concept of glucolipid metabolic disease（GLMD） and put forward the concept of ＂pivot liver of metabolic regulation system＂. In addition, we developed the therapeutic strategy of ＂modulating liver, starting pivot and cleaning turbidity＂, for the comprehensive and integrated treatment and prevention of these diseases. The theory of GLMD shared the critical characteristics with precision medicine, taking its own specialty. Finally, the content and approaches for the research of GLMD were proposed, and some essential and core fields in the precision medical research for GLMD were profoundly analyzed and prospected.

关 键 词：糖脂代谢病 糖代谢紊乱 脂代谢紊乱 精准医学 

分 类 号：R29[医药卫生—民族医学]