补肾调经膏方对肾虚型卵巢早衰患者性激素水平的影响  

Effect of Bushen Tiaojing Recipe Extract on Sexual Hormone Levels of Premature Ovarian Failure Patients with Kidney Deficiency Syndrome

作　　者：徐碧红 李茂清 熊思艺 赵晓东 

机构地区：[1]江门市五邑中医院,广东江门529031 [2]梅州市残联康复医院,广东梅州514000 [3]广州中医药大学,广东广州510405

出　　处：《广州中医药大学学报》2017年第2期167-172,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药强省科研课题(编号:20151130)

摘　　要：【目的】观察补肾调经膏方治疗肾虚型卵巢早衰(POF)的临床疗效及其对患者性激素水平的影响。【方法】将75例肾虚型卵巢早衰患者随机均分为中药组、膏方组和西药组各25例。中药组给予补肾调经方辨证治疗,膏方组给予补肾调经膏方治疗,西药组给予激素替代治疗(HRT)。3组均以28 d为1个疗程,连续治疗3个疗程,治疗结束后随访3个月。比较3组的临床疗效及治疗前后临床症状评分、月经改善情况、性激素[雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)]水平的变化情况。【结果】13组各脱落2例,实际共69例完成试验。2中药组、膏方组总有效率分别为73.91%、78.26%,优于西药组的52.17%(P<0.05)。3治疗后,中药组、膏方组能明显地改善各项临床症状(P<0.05或P<0.01),而西药组仅月经异常改善(P<0.01),中药组、膏方组在改善临床症状方面优于西药组(P<0.05或P<0.01)。4中药组、膏方组的月经改善率、月经改善时间优于西药组(P<0.05),复发率低于西药组(P<0.05)。5中药组、膏方组在升高血清E2水平,降低FSH、LH水平方面优于西药组(P<0.05或P<0.01)。6中药组、膏方组的不良反应率均为4.35%,低于西药组的13.04%(P<0.05)。【结论】补肾调经膏方具有药物浓度高,作用较稳定、缓和、持久,携带和服用方便的优点,其治疗肾虚型卵巢早衰的疗效确切,能有效地缓解临床症状,恢复正常月经和调节血清性激素水平,患者月经异常复发率低,不良反应少。Objective To investigate the clinical efficacy of Bushen Tiaojing Recipe Extract（an extract preparation of Chinese herbal medicine with the actions of tonifying kidney and regulating menstruation） for the treatment of kidney deficiency type of premature ovarian failure（POF）,and to observe the effect of the extract formula on sexual hormone levels of POF patients. Methods A total of 75 POF patients were randomly divided into Chinese medicine（CM） decoction group, CM extract group and western medicine（WM） group, 25 cases in each group. CM decoction group was treated with the decoction of Bushen Tiaojing Recipe（a decoction recipe for tonifying kidney and regulating menstruation）, CM extract group was treated with Bushen Tiaojing Recipe Extract,and WM group was treated with hormone replacement therapy（HRT）. Twenty-eight days constituted one treatment course,and the treatment for the 3 groups lasted 3 continuous courses. After treatment,the patients were followed up for 3 months.Clinical efficacy of the 3 groups was evaluated,and clinical symptom scores,the improvement of menstruation and the changes of sexual hormones of estrogen（E2）,follicle-stimulating hormone（FSH）and luteinizing hormone（LH）were observed before and after treatment. Results（1） Two cases of each group dropped out, and a total of 69 patients completed the study.（2）The total effective rate of CM decoction group and CM extract group was 73.91%,78.26% respectively,higher than 52.17% of WM group（P〈0.05）.（3）After treatment, clinical symptoms of CM decoction group and CM extract group were obviously improved（P〈0.05 or P〈0.01 compared with those before treatment）,while WM group only had an effect on improving the abnormal menstruation（P〈0.01 compared with that before treatment）. CM decoction group and CM extract group had better effect on improving the clinical symptoms than WM group（P〈0.05 or P〈0.01）.（4） CM decoction group and CM extract group had higher menstrual improvement rat

关 键 词：卵巢早衰 膏方 补肾调经方 激素替代疗法 性激素 

分 类 号：R271.175[医药卫生—中医妇科学]