局部外敷五味双柏散对原发性肝癌癌性疼痛的缓解作用及对血液流变学指标的影响  

Effect of Local External Application of Wuwei Shuangbai Powder on Cancer Pain and Hemorheology Indexes of Primary Liver Cancer Patients

作　　者：李丹青[1] 孙玲玲[1] 林洁衡[1] 

机构地区：[1]广州中医药大学第一附属医院肿瘤中心肿瘤一区,广东广州510405

出　　处：《广州中医药大学学报》2017年第2期177-180,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家"十一.五"科技支撑计划中医药项目(编号:2008BAI53B002)

摘　　要：【目的】探讨五味双柏散外敷对原发性肝癌癌性疼痛的缓解作用及对血液流变学指标的影响。【方法】采用随机、双盲、对照的临床研究,将60例原发性肝癌癌性疼痛患者随机分为治疗组和对照组,每组各30例。治疗组给予五味双柏散局部外敷+安慰剂胶囊口服治疗,对照组给予安慰剂局部外敷+塞来西布胶囊口服治疗,2组均以7 d为1个疗程,观察2组治疗后对患者疼痛数字分级法(NRS)评分及外周血血液流变学指标的影响。【结果】(1)治疗后,2组患者疼痛NRS评分均较治疗前减少(P<0.05或P<0.01),表明2组对原发性肝癌癌性疼痛均有一定程度的缓解作用,且治疗组的缓解作用优于对照组(P<0.05)。(2)治疗后,治疗组各项血液流变学指标均明显低于对照组,2组比较,除红细胞压积外,差异均有统计学意义(P<0.05或P<0.01)。【结论】五味双柏散外敷治疗原发性肝癌癌性疼痛疗效显著,其具体作用机理可能与改善肝癌患者血液流变学有关。Objective To study the effect of external application of Wuwei Shuangbai Powder on relieving primary liver cancer pain and to observe its effect on hemorheology indexes. Methods A double-blind, randomized and controlled trial was carried out in 60 primary hepatocellular carcinoma patients with cancer pain. The patients were divided into control group and treatment group, 30 cases in each group. The treatment group was given external application of Wuwei Shuangbai Powder and oral use of placebo capsules,and the control group was given external application of placebo powder and oral use of celecoxib capsules. The treatment for the two groups lasted for 7 days.Before and after treatment,pain was scored by Numeric Rating Scale（NRS）,and the peripheral blood hemorheology indexes of both groups were observed. Results（1） After treatment, the NRS pain scores of both groups were decreased compared with those before treatment（P〈0.05 or P〈0.01）,and the scores of the treatment group were significantly lower than those of the control group（P〈0.05）,indicating that the treatment group had better effect on relieving cancer pain.（2）After treatment, the indexes of hemorheology of treatment group were significantly higher than those of the control group, and the differences of the indexes except the hematocrit were significant between the two groups（P〈0.05 or P〈0.01）. Conclusion Wuwei Shuangbai Powder is effective for the treatment of primary liver cancer pain. The mechanism may be related to the improvement of hemorheology of liver cancer patients.

关 键 词：五味双柏散 原发性肝癌 癌性疼痛 血液流变学 

分 类 号：R273.57[医药卫生—中西医结合]