胰腺癌放疗相关胃、十二指肠溃疡发生的危险因素分析  

Gastric or duodenal ulcer induced by radiotherapy in patients with pancreatic cancer：an analysis of risk factors

作　　者：郭小陪 魏华琳[1] 陈晓[1] 刘建辉[1] 张夏璐[1] 周平[1] 

机构地区：[1]空军总医院肿瘤放疗科,北京100142 [2]空军总医院肿瘤放疗科,北京100142

出　　处：《肿瘤研究与临床》2017年第1期15-19,共5页Cancer Research and Clinic

基　　金：首都卫生发展科研专项基金（2011-5041-04）

摘　　要：目的：初步探讨胰腺癌放疗中导致放射性胃、十二指肠溃疡发生的危险因素。方法收集空军总医院112例胰腺癌放疗前、后均行胃镜检查患者的临床资料，将患者放疗前、后胃镜下的表现进行自身对比。对可能导致放射性溃疡发生的危险因素进行单因素分析及logistic多因素回归分析。结果112例患者的放射性溃疡总发生率为42.0%（47／112）。既往有溃疡史和2级以上急性胃肠道不良反应为发生放射性溃疡的独立危险因素（P值分别为0.036、0.030），其余因素对溃疡的发生均无影响（均P〉0.05）。结论在胰腺癌放疗中，对于既往有溃疡史及2级以上胃肠道不良反应的患者，应警惕放射性胃、十二指肠溃疡的发生。Objective To analyze the endoscopic observation of gastroduodenal ulcer radioactive injury induced by pancreatic cancer radiotherapy, and to preliminary investigate the risk factors of radiation-induced ulcer after radiotherapy in patients with pancreatic cancer. Methods A total of 112 patients with pancreatic cancer who accepted gastroscopy before and after radiotherapy at Air Force General Hospital were collected. Self-comparative study of gastroscopic findings was performed on these patients. Single factor analysis and the logistic regression analysis model were used to analyze whether the clinical factors were likely to affect the radiation-induced ulcer or not. Results The total incidence of radiation-induced ulcer was 42.0 % （47/112） in 112 patients. The history of ulcer and grade 2 or more acute gastrointestinal symptoms （P= 0.036, P= 0.030） were the independent risk factors of radiation-induced ulcer. The rest clinical factors had no influence on the radiation-induced ulcer （all P〉0.05）. Conclusion In the radiotherapy of pancreatic cancer, patients who has the history of ulcer or grade 2 or more acute gastrointestinal symptoms should be alert to the occurrence of radiation-induced ulcer.

关 键 词：胰腺肿瘤 放射疗法 消化性溃疡 放射性损伤 

分 类 号：R730.55[医药卫生—肿瘤] R735.9[医药卫生—临床医学]