替罗非班用于冠心病患者 PCI 术后抗炎的效果观察  

Effect of tirofiban on PCI postoperative antinflammation in patients with coronary heart disease

作　　者：孙智慧[1] 

机构地区：[1]河南省郑州人民医院心血管内科二病区,450053

出　　处：《中国实用医刊》2017年第3期16-18,共3页Chinese Journal of Practical Medicine

摘　　要：目的：观察替罗非班用于冠心病患者经皮冠状动脉介入治疗（PCI）术后抗炎效果及术后不良事件影响。方法以2012年1月至2014年3月66例行 PCI 术的冠心病患者为研究对象，按随机数字表法分为观察组和对照组，每组33例，对照组术后给予常规基础治疗，观察组术后在对照组基础上另联合替罗非班治疗，对两组治疗后炎性指标[白细胞介素-8（ IL-8）、白细胞介素-10（ IL-10）]变化及两组术后不良事件情况进行观察比较。结果对照组炎性指标手术前后比较差异有统计学意义（P ＜0.05），术后24 h 观察组 IL-8、IL-10及 IL-8/ IL-10均低于对照组，差异有统计学意义（P ＜0.05）。观察组给药后不良事件发生总发生率低于对照组，差异有统计学意义（P ＜0.05）。结论替罗非班用于冠心病患者 PCI 术后有较好的抗炎效果，并有效降低术后不良事件发生，临床积极作用显著，有推广应用价值。Objective To observe the effect of tirofiban on percutaneous coronarg intervention （PCI）postoperative antinflammation in patients with coronary heart disease and postoperative adverse events. Methods Sixty-six patients with coronary heart disease who received PCI from January 2012 to March 2014 were selected as the research objects,they were divided into the observation group and the control group（with 33 cases in each group）by random number table. After operation,the control group received ordinary basic treatment,the observation group was given tirofiban on the basis of the control group,inflammatory indexes[interleukin-8（IL-8）,interleukin-10（IL-10）]changes in the two groups were compared, adverse events after operation in the two groups were observed and compared.＆nbsp;Results Compared with those before operation,inflammatory indexes after administration in the two groups increased,but there was significant difference only in inflammatory indexes in the control group before and after the operation（P 〈 0. 05）,IL-8,IL-10 and IL-8 / IL-10 in the observation group 24 h after operation were significantly less than those in the control group（ P 〈 0. 05）. The total rate of adverse events after administration in the observation group was significantly lower than that in the control group（ P 〈 0. 05）. Conclusions Antinflammatory effect of tirofiban in patients with coronary heart disease after PCI is better,which can reduce the incidence of postoperative adverse events effectively,the clinical positive effect is significant,and it has development and application value.

关 键 词：冠心病 经皮冠状动脉介入治疗术 替罗非班 抗炎 

分 类 号：R541.4[医药卫生—心血管疾病]