丹酚酸B脂化乳的制备及其稳定性研究  

Preparation and stability of Salvianolic Acid B Lipo-emul

作　　者：陈芳宁 张秀荣[1] 王秀丽[1] 邱仁杰[1] 雷晓晴 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《现代药物与临床》2017年第2期179-182,共4页Drugs & Clinic

基　　金：北京市自然科学基金资助项目(7132118)

摘　　要：目的制备丹酚酸B脂化乳,并考察其在人工胃肠液中的稳定性。方法制备丹酚酸B脂化乳粒、脂化乳。采用紫外分光光度法测定并比较脂化乳粒、脂化乳中丹酚酸B在人工胃液和人工肠液中的变化。结果不同制剂中丹酚酸B在人工胃液中的量均有所降低,但脂化乳和脂化乳粒均较水溶液中丹酚酸B的量高,3 h后丹酚酸B水溶液中药物的量分别较脂化乳、脂化乳粒少19.3%、6.4%。不同制剂中丹酚酸B在人工肠液中的量均有所降低,但脂化乳、脂化乳粒均较水溶液中丹酚酸B的量高,6 h后丹酚酸B水溶液中药物的量分别较脂化乳、脂化乳粒少32.7%、5.3%。结论丹酚酸B脂化乳、脂化乳粒均能提高人工胃、肠液中所包载药物的稳定性;且脂化乳效果优于脂化乳粒。Objective To prepare Salvianolic Acid B Lipo-emul, and study stability of salvanolic acid B in artificial gastrointestinal fluid. Methods Salvianolic Acid B Lipo-emul and Lipo-emul Particles were prepared. UV spectrophotometry was used to determine concentration of salvanolic acid B in different preparations. Concentration changes of salvanolic acid B in different preparations in artificial gastrointestinal fluid were compared. Results The contents of salvianolic acid B of different preparations in artificial gastric juice were decreased, but the index in lipo-emul and lipo-emul particle was higher than those in solution. In artificial gastric juice, salvanolic acid B content in solution was 19.3% and 6.4% less than lipo-emul and lipo-emul particle after 3 h. The contents of salvianolic acid B of different preparations in artificial intestinal juice were also decreased, and salvianolic acid B content in solution was 32.7% and 5.3% less than lipo-emul and lipo-emul particle after 6 h. Conclusion Salvianolic Acid B Lipo-emul and Lipo-emul Particles can improve the loaded-drugs＇ stability in the artificial gastrointestinal fluid. And Lipo-Emul＇s stability is better than Lipo-Emul particle＇s.

关 键 词：丹酚酸B 脂化乳 脂化乳粒 人工胃液 人工肠液 稳定性 

分 类 号：R944[医药卫生—药剂学]