妊娠期抗癫痫药物的药代动力学变化及胎盘转运特征  

Antiepileptic Drugs during Pregnancy:Changes in Pharmacokinetics and Characteristics of Transplacental Transfer

作　　者：陈亚南[1] 刘立民[1] 徐善森 肇丽梅[1] 

机构地区：[1]中国医科大学附属盛京医院药学部,辽宁沈阳110004

出　　处：《药学进展》2017年第2期124-131,共8页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81673510)

摘　　要：癫痫是一种常见的神经系统慢性疾病,多数患者妊娠期需继续应用抗癫痫药物(AEDs)治疗,以控制癫痫发作。但妊娠期妇女体内一系列生理变化可改变AEDs的药代动力学行为,导致癫痫发作并危及胎儿的生长发育。基于此,综述妊娠期AEDs的药代动力学变化及胎盘转运特征,为妊娠期癫痫患者的精准合理用药提供参考。Epilepsy is a common chronic neurological disorder. The majority of women with epilepsy during pregnancy need to continue the use of antiepileptic drugs（AEDs） to control seizures. However, a series of physiologic changes that take place in women during pregnancy can alter the pharmacokinetics of AEDs, resulting in an increased risk of seizures and even damage to fetal growth and development. Therefore the changes in pharmacokinetics of AEDs and characteristics of their transplacental transfer during pregnancy were reviewed, so as to provide some reference for precise and rational use of AEDs in patients with epilepsy during pregnancy.

关 键 词：抗癫痫药物 妊娠期 药代动力学 胎盘转运 

分 类 号：R969.1[医药卫生—药理学]