前列腺素E1脂微球载体制剂联合西洛他唑治疗老年下肢动脉硬化闭塞症的疗效分析  

Curative effect of lipo prostaglandin E1 combined with cilostazol on senile arteriosclerosis obliterans of the lower limbs

作　　者：牟财国 蔡杨阳[1] 王弋萍 沈洁[1] 

机构地区：[1]台州市第一人民医院血管外科,浙江台州318020

出　　处：《中华全科医学》2017年第3期427-430,共4页Chinese Journal of General Practice

摘　　要：目的探讨前列腺素E1脂微球载体制剂(Lipo-PGE1)联合西洛他唑对老年下肢动脉硬化闭塞症(ASO)的疗效。方法以入院病例号为编号,根据随机数字表,将160例老年ASO患者随机分成3组,Lipo-PGE1组(53例)、西洛他唑组(52例)、联合组(55例)。治疗2个疗程后比较临床疗效、血流动力学变化、甲襞微循环、踝肱指数改善及炎症因子改变情况。结果联合组疗效、总有效率均优于西洛他唑组和Lipo-PGE1组(P<0.05),西洛他唑组和Lipo-PGE1组有效率对比,差异无统计学意义(P>0.05);联合组的足背动脉处的峰值血流速度、血流搏动指数、阻力指数均低于西洛他唑组和Lipo-PGE1组(P<0.05),Lipo-PGE1组峰值血流速度、血流搏动指数、阻力指数均低于西洛他唑组(P<0.05);联合组的甲襞微循环积分和ABI均优于其他2组(P<0.05),Lipo-PGE1组甲襞微循环积分和ABI优于西洛他唑组(P<0.05);联合组的C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)和细胞间黏附分子-1(ICAM-1)均低于其他2组(P<0.05),Lipo-PGE1组CRP、TNF-α、IL-6和ICAM-1低于西洛他唑组(P<0.05)。结论 Lipo-PGE1联合西洛他唑可彼此增加治疗老年ASO的临床疗效,有效改善患者血流动力学水平,临床治疗效果值得肯定。Objective To investigate the curative effect of Lipo prostagjandin E1 （Lipo-PGE1） combined with cilostazol on senile arteriosclerosis obliterans of the lower limbs. Methods The 160 cases of elderly patients with arteriosclerosis obliterans of the lower limbs were divided into Lipo-PGE1 group （n = 53 ）, cilostazol group（ n = 52 ）, combined group（ n = 55 ） according to the random number table. After 2 courses of treatment, the clinical efficacy, hemodynamic changes, and the improvement of nailfold microcireulation, ankle braehial index （ABI） and inflammatory factors were compared among the three groups. Results Curative effect and The total effective rate, of the combined group, which was better than both of cilostazol group and Lipo-PGE1 group（ P 〈 0.05 ） ,the difference between eilostazol group and Lipo-PGE1 group was not statistically significant （ P 〉 0.05 ） ; After the treatment, the peak systolic velocity, blood flow pulsation index and resist- ance index in dorsalis pedis artery was lower than those of eilostazol group and Lipo-PGE1 group（P 〈0.05） ,those of Li- po-PGE1 group were lower than those in the cilostazol group（ P 〈 0.05 ） ; Nailfold microeirculation integral and ABI of the combination group were better than those of cilostazol group and Lipo-PGE1 group（ P 〈 0.05 ）, those of Lipo-PGE1 group were better than those of cilostazol group （ P 〈 0.05 ） ; The levels of C-reactive protein, TNF-α, IL-6 and ICAM-1 of the combination group were lower than those of cilostazol group and Lipo-PGE1 group （P 〈 0.05 ）, those of Lipo-PGE1 group were lower than those in the eilostazol group （ P 〈 0.05 ）. Condusion Lipo-PGE1 combined with eilostazol can increase cooperatively the curative effect of arteriosclerosis obliterans of the lower limbs in elderly patients, effectively improve the patients ＇ hemodynamie parameters.

关 键 词：下肢动脉硬化闭塞症 老年患者 前列腺素E1脂微球载体制剂 西洛他唑 

分 类 号：R543.5[医药卫生—心血管疾病] R972.6[医药卫生—内科学]