通心络胶囊联合阿托伐他汀与单用阿托伐他汀对冠心病患者血脂、炎症因子水平的影响比较  

Effect of Tongxinluo capsule combined atorvastatin on blood lipids and inflammatory factor in patient with coronary heart disease

作　　者：潘嘉西[1] 章敏学[1] 郑巨克[1] 姜进克[1] 陈世志[1] 王伟伟[1] 

机构地区：[1]温州医科大学附属第三医院心血管内科,浙江温州325200

出　　处：《中华全科医学》2017年第3期452-453,478,共3页Chinese Journal of General Practice

摘　　要：目的比较通心络胶囊联合阿托伐他汀与单用阿托伐他汀对冠心病患者血脂、炎症因子水平的影响。方法将温州医科大学附属第三医院2014年3月—2016年3月收治的172例冠心病患者采用随机数字法分为2组,每组86例。对照组给予阿托伐他汀,观察组在此基础上加用通心络胶囊。治疗前、后,检测患者血脂[(甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)]和炎症因子(IL-4、IL-10和IL-18)水平,并统计治疗效果和不良反应情况。结果观察组总有效率为74.4%,显著高于对照组的51.1%(P<0.05)。治疗前,2组TG、TC、LDL-C、HDL-C水平比较差异无统计学意义(P>0.05)。治疗后,2组TG、TC、LDL-C、HDL-C水平显著改善(P<0.05),观察组TG、TC、LDL-C、HDL-C水平改善显著优于对照组(P<0.05)。治疗前,2组IL-4、IL-10、IL-18水平比较差异无统计学意义(P>0.05)。治疗后,2组IL-4、IL-10、IL-18水平显著改善(P<0.05),观察组IL-4、IL-10、IL-18水平改善显著优于对照组(P<0.05)。2组均未出现严重不良反应。结论相比于单用阿托伐他汀,通心络胶囊联合阿托伐他汀可有效改善冠心病患者血脂、炎症因子水平,治疗效果满意。Objective To compare the effect of Tongxinluo capsule combine with atorvastatin and atorvastatin alone on the levels of blood lipids and inflammatory factors in patient with coronary heart disease. Methods One hundred and seven- ty-two eases of coronary heart disease in our hospital from March, 2014 to March, 2016 were randomly divided into two groups by random number method with 86 cases in each group. The patients in the control group were given atorvastatin, while the patients in the observation group were added Tongxinluo capsule based on the treatment of the control group. Be- fore and after the treatment, the levels of blood lipids （ TG, TC, LDL-C and HDL-C） and inflammatory factors （ IL-4, IL-10,and IL-18） of the two groups were tested, and the efficacy and adverse reaction were compared between the two groups. Results The total effective rate of the observation group was 74.4% ,which was significantly higher than 51.1% of the control group（P 〈 0.05）. Before the treatment,the difference in the levels of TG,TC, LDL-C and HDL-C between the two groups were not significantly （ P 〉 0.05 ）. After the treatment, the levels of TG, TC, LDL-C and HDL-C of both groups were significantly improved（P 〈 0.05 ）, especially in the observation group （P 〈 0.05 ）. Before the treatment, the difference in the levels of IL-4, IL-10 and IL-18 between the two groups were not significantly（P 〉 0.05）. After the treat- ment,the levels of IL-4 ,IL-10 and IL-18 of both were significantly improved（ P 〈 0.05 ）, and there was also significant difference in the levels of IL-4, IL-10 and IL-18 between the observation group and the control group （P 〈 0.05）. There was no serious adverse reaction in both groups. Conclusion Compared with atorvastatin alone,Tongxinluo capsule com- bined atorvastatin can more effectively improve the levels of blood lipid and inflammatory factor of patient with coronary heart disease, and the efficacy is satisfied.

关 键 词：冠心病 血脂 炎症因子 通心络 阿托伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病] R446.11[医药卫生—内科学]