尿石2号方对肾结石ESWL术后患者尿NAG、γ-GT及血清β2-MG、NAG、CysC水平的影响  

Influence of Niaoshi No.2 Formula on Urinary NAG,γ-GT,Serum β2-MG,NAG and CysC in Patients with Kidney Stone After ESWL Surgery

作　　者：陈宝国[1] 邱丽瑛[1] 杨柳[1] 胡羽健[1] 熊玲珠[1] 杨思霞[1] 

机构地区：[1]江西中医药大学附属医院,江西南昌330006

出　　处：《南京中医药大学学报》2017年第1期19-22,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江西省科技支撑计划(20141BBC70054)

摘　　要：目的观察肾结石体外冲击波碎石术(ESWL)对肾脏的损伤及中药尿石2号方的防治作用。方法 60例肾结石ESWL术患者随机分为2组,碎石后常规治疗为适当多饮水、抗感染、体位排石和对症处理,治疗组ESWL术前3d至术后7d服用尿石2号方。2组分别于ESWL术前、术后24、72、168h检测尿N-乙酰-β-D-葡萄糖苷酶(NAG)、γ-谷氨酰转移酶(γ-GT),血清β_2-微球蛋白(β_2-MG)、NAG、血清胱抑素C(CysC)水平变化。结果 ESWL术后24h2组尿NAG、γ-GT、β_2-MG、NAG、CysC水平均明显升高,与ESWL术前比较有显著性差异(P<0.01);ESWL术后24h、72h治疗组尿NAG、血清NAG值均明显低于对照组(P<0.05~0.01);2组ESWL术后168h尿酶均恢复正常。2组结石排石率达到100%,结石排净率治疗组(96.67%)高于对照组(73.33%)(P<0.01)。结论肾结石ESWL术可引起肾脏的损伤,但在一定的时间与范围内是可逆的;中药尿石2号方对肾结石ESWL术后肾脏的损伤具有快速、较好的防治作用。OBJECTIVE To explore the biological effects of extracorporeal shock-wave lithotripsy（ESWL） on kidney dam- age as well as the preventive and therapeutic effects of Niaoshi No. 2 Formula. METHODS 60 cases with kidney stone who re- ceived ESWL surgery were randomly divided into two groups. Patients in the control group were given the routine treatment including giving large volume of water, resisting infection, removing urinary stone based on body position and dealing with the symptoms, while those in the treatment group were given Niaoshi No. 2 Formula from three days before ESWL surgery to the seventh day after the surgery. Changes of urinary NAG, gamma-GT, serum beta2-MG, NAG and CysC were detected before ESWL and 24 h, 72 h, and 168 h after operation in the two groups. RESULTES The contents of urinary NAG, γ-GT, serum 2-MG, NAG and CysC obviously increased 24 h after surgery when compared with the situations before（P〈0.01）; Urinary NAG and serum NAG in the treatment group were evidently lower than those of the control group 24 h and 72 h after ESWL surgery（P〈0.05-0.01）. Ureases of both groups were able to return to normal situation within 168 hours after surgery. CONCLUSION ESWL surgery can cause damage to kidney, which is reversible within a certain time and scope. Chinese medi- cine Niaoshi No. 2 Formula has swift and good effects on kidney damage in patients after receiving ESWL surgery.

关 键 词：ESWL 肾损伤 中医药治疗 尿石2号方 

分 类 号：R256.5[医药卫生—中医内科学]