耳后注射甲泼尼龙对全聋型突发性聋疗效分析  

Analysis of the effect of postaurieal injection of methylprednisolone on sudden total hearing loss

作　　者：许鹏[1] 赵群[1] 王英力 王洪芹[1] 冯丽春[1] 兰娜 

机构地区：[1]沧州市中心医院耳鼻喉科,河北沧州061000 [2]沧州市人民医院耳鼻喉科,河北沧州061000

出　　处：《兰州大学学报（医学版）》2017年第1期56-59,共4页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的研究耳后注射甲泼尼龙对全聋型突发性聋各频率疗效的影响。方法选取住院治疗的突发性聋中全聋型者,按照有无耳后注射甲泼尼龙分为耳后注射组及非耳后注射组,分别比较两组治疗有效率、治愈率及治疗前后5个频段提高幅度(125—250 Hz、125—500 Hz、500—2 000 Hz、4 000—8 000 Hz及250—4 000 Hz的平均值)。结果耳后注射组各频段提高值依次为29.25±5.14,29.67±4.36,26.50±3.60,26.00±7.04,26.99±3.75 d BHL;非耳后注射组各频段提高值依次为14.00±4.66,14.77±4.38,16.52±3.77,12.28±2.93,15.40±3.63 d BHL。耳后注射组和非耳后注射组比较,125—250 Hz平均值频段P=0.028,125—500 Hz平均值频段P=0.021,差异有统计学意义。耳后注射组和非耳后注射组有效率分别为80%和44%,χ~2=6.00,P=0.014,差异有统计学意义。结论耳后注射甲泼尼龙治疗突发性聋安全有效,对全聋型突发性聋可明显提高治疗有效率,而且对低频听力的提高贡献明显。Objective To explore the effect of postaurieal methylprednisolone injection on sudden total hearing loss. Methods Retrospectively analyze the patients with sudden hearing loss, selected and divided the total deafness type into two group, postaurieal methylprednisolone injection group and nonpostaurieal methylprednisolone injection group, respectively. The treatment efficiency, the cure rate and the increased values of five frequency bands（the average value of 125—250 Hz, the average value of 125—500 Hz, the average value of 500 —2 000 Hz, the average value of 4 000—8 000 Hz and the average value of 250— 4 000 Hz）before and after injection were compared. Results The increased valuses of the five frequency bands in the postaurieal injection group are 29.25±5.14, 29.67±4.36, 26.50±3.60, 26.00±7.04, 26.99±3.75 d BHL, the increased value of each band in the nonpostaurieal injection group are 14.00±4.66, 14.77±4.38, 16.52±3.77,12.28±2.93, 15.40±3.63 d BHL, respectively. The postaurieal injection group showed more obviously increasein the average value of 125—250 Hz（P=0.028） and the average value of 125— 500 Hz（P=0.021）. The effective rate of the two groups are 80% and 44% respectively, χ-2=6.00, P=0.014. Conclusion Postaurieal injection of methylprednisolone is safe and effective in the treatment of sudden total hearing loss. Its cure rate is higher and the improvement on low frequencies hearing is better than the high frequencies.

关 键 词：突发性聋 给药方式 疗效 

分 类 号：R453.9[医药卫生—治疗学]