睡眠呼吸暂停低通气综合征患者血氧变化与相关呼吸事件的相关性的研究  

The relationship between oxygen saturation and related respiratory events in patients with obstructive sleep apnea-hypopnea syndrome

作　　者：王婷婷[1] 黄少雄[1] 张湘民[2] 张孝文[3] 罗语溪[1,4] 

机构地区：[1]中山大学工学院,广州510006 [2]中山大学第六附属医院耳鼻咽喉科 [3]广州医科大学第一附属医院耳鼻咽喉科 [4]广东省传感技术与生物医疗仪器重点实验室

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第3期170-173,179,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金(No:81570904);广东省自然科学基金(No:2014A030313215);广州市科技惠民项目(No:2014Y2-00162)

摘　　要：目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠过程中的血氧(SaO_2)变化与事件恢复情况的相关关系。方法:将呼吸事件按照恢复通气情况的不同分为伴随第二事件(SRE,未恢复正常通气)和不伴随第二事件(N-SRE,恢复正常通气)两类,以提取事件后SaO_2变化段的4个特征值作为指标,比较不同病情的患者各血氧指标的差异性,以及个体内归一化后SRE血氧变化组和N-SRE血氧变化组各指标的对比。结果:SRE血氧变化组和N-SRE血氧变化组成对t检验的结果显示,SRE组SaO_2的下降程度、氧降速率、持续时间都要极显著大于N-SRE组(P<0.01),SRE组SaO_2的下降最低值极显著小于N-SRE组(P<0.01)。中度和重度患者的血氧指标对比均具有显著性差异。结论:OSAHS患者的不同病情会影响SaO_2的相关指标的变化,且SaO_2的相关指标和事件恢复情况存在相关关系。本研究为呼吸事件恢复的进一步研究提供更多的依据,了解如何能从呼吸事件中较快恢复正常通气为治疗OSAHS提供可能的方案。Objective： To explore the relationship between variation of hemoglobin saturation and related respiratory events in patients with obstructive sleep apnea and hypopnea syndrome（OSAHS）. Method： According to the SaO2 ,the respiratory events were divided into two groups, followed or not followed the second events （SRE and N-SRE）. Four features were extracted from SaO2 and compared within groups under SRE versus N-SRE, and comparisons were also developed between moderate patients and severe patients. Result： △SaO2, max, the duration and Dvmax was significantly higher in SRE than N-SRE（P〈0.01）, while Nadir was significantly lower in SRE than N-SRE（P〈0.01）. There was also significant difference in the blood oxygen index between moderate and severe patients. Conclusion ： The change of SaO2 is correlated with the ventilation restoration. The results also suggest that the severity of the patient＇s condition will affect the change of SaO2 related indicators. This study provides information on the further study of ventilation restoration. Moreover, this study may provide a possible solution for the treatment of OSAHS.

关 键 词：呼吸事件恢复 血氧 阻塞性 睡眠呼吸暂停低通气综合征 

分 类 号：R563.8[医药卫生—呼吸系统]