基于药物-磷脂复合物的纳米释药系统研究进展  

Nanodrug delivery systems based on drug-phospholipid complex:research advances

作　　者：孟令玮 王玉丽[2] 高春生[2] 黄伟[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所药物制剂研究室,北京100050 [2]军事医学科学院毒物药物研究所药物制剂研究室,北京100850

出　　处：《国际药学研究杂志》2017年第1期40-46,共7页Journal of International Pharmaceutical Research

摘　　要：磷脂是体内生物膜的主要成分,将其与药物复合形成药物-磷脂复合物,可改善药物的溶解性和稳定性,提高生物利用度。在此基础上,以药物-磷脂复合物为中间载体进一步构建的纳米释药系统成为近年来药剂学领域的研究热点。该类纳米释药系统兼具药物-磷脂复合物和纳米制剂的双重特点,既能提高药物的溶解性、稳定性和生物利用度,也可实现靶向给药,减少用药剂量,降低毒副作用,因此应用前景广阔。本文对药物-磷脂复合物组成结构、特点、形成机制以及基于药物-磷脂复合物构建的各类纳米释药系统的研究进展进行综述。Phospholipids are the major components of the biomembrane. Combining the phospholipids and the drugs to form drug-phospholipid complex can improve the solubility,stability and bioavailability of the drugs. On this basis,the nanodrug delivery system,which is constructed with the drug-phospholipid complex as an intermediate carrier,has become a research hot spot in the field of pharmaceutics. This kind of nanodrug delivery system can not only improve the solubility,stability and bioavailability of drugs,but also carry out the targeted drug delivery,decrease the drug dose and reduce the side effects,thereby it is very promising.In this review,we describe the structural composition,characteristics,forming mechanism of the drug-phospholipid complex and the research progresses in a variety of nanodrug delivery systems based on drug-phospholipid complex.

关 键 词：药物-磷脂复合物 纳米释药系统 生物利用度 溶解度 稳定性 

分 类 号：R943[医药卫生—药剂学]