肝纤维化乙型肝炎患者血清脂肪细胞因子水平特点的研究  

Serum levels of fatty cytokines in hepatitis B patients with liver fibrosis

作　　者：徐文丽[1] 袁文斌[2] 丁建[3] 金文君[1] 

机构地区：[1]浙江省湖州市中心医院检验科,313000 [2]浙江省湖州市中心医院肝胆外科,313000 [3]浙江省湖州市中心医院消化内科,313000

出　　处：《中华全科医师杂志》2017年第2期114-117,共4页Chinese Journal of General Practitioners

摘　　要：目的 探讨肝纤维化乙型肝炎患者脂肪细胞因子水平特点.方法 以2014年4月1日至2016年3月31日期间在温州市中心医院消化内科诊治的56例肝纤维化乙型肝炎患者为病例组,其中男性32例、女性24例,平均年龄（46.8±11.2）岁,BMI （21.8±2.7） kg/m^2,行血清脂肪细胞因子网膜素、瘦素、脂联素、内脏脂肪素和ALT、AST水平以及血HBV DNA水平检测;行肝组织活检并评价肝组织炎症活动度（HA）和肝组织纤维化分期（HF）.以同时56例健康查体者为对照组,其中男性30例、女性26例,平均年龄（43.8±12.9）岁,BMI（22.3±2.4） kg/m^2.结果 病例组血清网膜素水平显著高于对照组[（358±119）比（305±108） μg/L,t=2.236,P=0.037].血清网膜素（r值分别为0.211、0.178、0.106）、内脏脂肪素（r值分别为-0.144、-0.133、-0.169）、瘦素（r值分别为-0.097、-0.084、-0.110）和脂联素水平（r值分别为-0.223、-0.189、-0.147）与肝功、HBV DNA水平无相关性（均P＞0.05）.低HA分度者（23例）与高HA分度者（33例）的脂肪细胞因子水平差异无统计学意义（P＞0.05）.高HF分期者（35例）网膜素水平显著高于21例低HF分期者[（398±130） μg/L比（292±120） μg/L,t=2.648,P=0.009],其他脂肪细胞因子水平之间差异无统计学意义（均P ＞0.05）.结论 肝纤维化乙型肝炎患者的网膜素水平升高,并且与肝纤维化严重程度相关.Objective To investigate the serum levels of fatty cytokines in hepatitis B patients with liver fibrosis.Methods Fifty six hepatitis B patients with liver fibrosis admitted in Wenzhou Central Hospital from April 2014 to March 2016 were recruited as case group and 65 healthy subjects as control group.Serum cytokines including omentin,leptin,adiponectin and visfatin were detected in both two groups and glutamyl endopeptidase （ALT）,aspartate aminotransferase （AST） and hepatitis B virus DNA were detected in the case group.Liver biopsy was performed in the case group and histologic activity （HA） and histologic fibrosis （HF） stage were evaluated.Results The level of omentin in the case group was significantly higher than that in the control group [（358-119） vs.（305 ± 108） μg/L,t =2.236,P =0.037].Serum omentin,visceral fat hormone,leptin and adiponectin were not associated with liver function and HBV-DNA （P 〉0.05）.There was no significant difference in adipocytokines levels between the low and high HA group （P 〉 0.05）.The level of omentin in high HF stage group was significantly higher than that in low HF stage group [（398 ± 130） vs.（292 ± 120） μg/L,t =2.648,P =0.009],while the other fatty cytokines did not show significantly differences between high and low HF groups （P 〉 0.05）.Conclusion Serum omentin level is elevated in hepatitis B patients with liver fibrosis and is associated with liver fibrosis severity.

关 键 词：肝硬化 肝炎 乙型 细胞因子 脂肪细胞 

分 类 号：R446.6[医药卫生—诊断学] R512.62[医药卫生—临床医学]