中国人粒细胞无形体病的研究进展  

Progress in study of human granulocytic anaplasmosis in China

作　　者：陶律延 梁张[1,4] 宝福凯[1,5,2,6,4] 柳爱华[1,5,2,6,3] 

机构地区：[1]昆明医科大学云南省高校热带传染病重点实验室,云南昆明650500 [2]昆明医科大学热带医学研究所,云南昆明650500 [3]昆明医科大学生物化学与分子生物学系,云南昆明650500 [4]云南省热带病示范型国际科技合作基地,云南昆明650500 [5]云南省公共卫生与疾病防控协同创新中心,云南昆明650500 [6]昆明医科大学病原生物学与免疫学系,云南昆明650500

出　　处：《中国热带医学》2017年第2期193-197,共5页China Tropical Medicine

基　　金：国家自然科学基金资助项目(No.81060134;81371835;31560051;81560596);云南省科技厅-昆明医科大学联合基金项目(云南省科技计划项目)(No.2010CD221;2011FB244;2012FB011;2013FZ057;2014FA011;2014FB001)

摘　　要：人粒细胞无形体病(HGA)是由嗜吞噬细胞无形体引起的一类人兽共患病,可经蜱叮咬的方式传播到人和动物体内,也可通过人-人的院内传播途径传播。1994年,美国首次报道威斯康星州一名患者感染HGA,随后该病呈世界性分布,在美洲、欧洲、澳洲、非洲及亚洲均有感染报道,目前已发展成为美国及欧洲第三大常见的媒介传播感染疾病。2006年,我国诊断出首例HGA,随后其感染逐年上升且分布广泛。以发热伴白细胞、血小板减少和多脏器功能损害为主要特点,该病无非常特异的临床症状,容易误诊,致使治疗不当导致病情恶化,甚至死亡,对我国人畜的健康构成极大的威胁。因此,对HGA的早期确诊对该病的有效治疗有着重要意义,其临床诊断需综合考虑流行病学、临床表现及实验室检查,治疗首选强力霉素。Human granulocytic anaplasmosis（HGA） is a kind of tick- borne zoonosis which caused by Anaplasma phagocytophilum. Besides,human-to-human transfusion can occur. Since a patient with HGA who was living in the Wisconsinof the United States was first described in 1994,then the disease shows worldwide distribution,it has been found in theAmericas,Europe,Australia,Africa and Asia. HGA is the third most common vector-borne infection in the USA and Europe.And the first HGA case in China was found in 2006. Then the cases are increasing and widely distributing in China. The mainclinical presentations consist of fever accompanied by leukopenia,thrombocytopenia,and multiple organ function damage. Itinduced a lot of misdiagnosis because of the non-specific clinical manifestation which will result in progressive deterioration ofthe patients,and even death. HGA threats people and livestock health seriously in China. Therefore,early diagnosis of HGAhas great significance to the effective treatment of the disease. The clinical diagnosis of HGA should be based on theepidemiology,clinical manifestation and laboratory examination. Doxycycline has been the first choice of HGA treatment.

关 键 词：人粒细胞无形体病 嗜吞噬细胞无形体 临床诊断 流行病学 临床表现 实验室检查 治疗 

分 类 号：R376[医药卫生—病原生物学]