膜分离技术应用于柴黄口服液的纯化分离工艺研究  

Study on extraction and purification of Caihuang oral liquid with membrane separation method

作　　者：宋逍[1] 段玺[2] 赵鹏[1] 唐志书[1] 王昌利[1] 

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]陕西中医药大学附属医院检验科,陕西咸阳712046

出　　处：《吉林中医药》2017年第2期183-187,共5页Jilin Journal of Chinese Medicine

基　　金：国家科技重大专项(编号:2011ZX09401-308-037);陕西省中医药管理局2013年度科研专项((编号:13-ZY015);陕西省中药制药重点学科专项基金资助(编号:1008);陕西省中药基础与新药研究重点实验室;国家中管局中药制剂三级实验室

摘　　要：目的探索膜分离技术应用于柴黄口服液纯化分离工艺的可行性。方法以醇沉处理的药液和以无机陶瓷膜和聚砜膜,进行膜分离处理的药液为研究对象,以黄芩苷、柴胡皂苷a为评价指标,结合物理化学参数p H、电导率、浊度、黏度的测定,考察膜分离法和醇沉分离法制得各制剂的指标性成分含量和稳定性差异。结果膜分离处理后的药液指标性成分的含量明显高于醇沉处理的药液,且有更好的稳定性。结论膜分离技术能有效提高柴黄口服液的质量,可应用于口服液的大生产过程。Objective Membrane separation technology was applied to Caihuang oral liquid in the process of extraction and purification.To explore the feasibi lity of this technology.Me thods The Study object is two kinds of Caihuang oral liquids,extract-alcohol precipitation liquid,or the inorganic ceramic membrane and polysulfone membrane disjunctive liquid. Evaluating indicator is liquid medicine e ffective component content（Baicalin and Saikosaponin a）.To compare the stability and evaluating indicator of two liquid of physical and chemical parameters of p H, conductivity, turbidity and viscosity after change.Results The content of the index components of the liquid membrane after the membrane separation treatment was significantly higher than that of the alcohol precipitation treatment, and had better stability.Conclusion Conclusion Membrane separation technology can effectively improve the quali ty of Caihuang oral liquid and can be used in oral liquid production process.

关 键 词：膜分离 醇沉 柴黄口服液 黄芩苷 柴胡皂苷A 

分 类 号：R283[医药卫生—中药学]