2-苄基-6-对甲苯磺酰基-2,6-二氮杂螺[3,3]庚烷的合成  

Synthesis of 2-Benzyl-6-tosyl-2,6-diazaspiro[3,3]heptane

作　　者：李秀芬[1] 黄龙江[1] 滕大为[1] 

机构地区：[1]青岛科技大学化工学院,山东青岛266042

出　　处：《青岛科技大学学报（自然科学版）》2017年第1期19-23,共5页Journal of Qingdao University of Science and Technology:Natural Science Edition

基　　金：山东省自然科学基金项目(ZR2014BL028)

摘　　要：以三溴新戊醇为原料,经与对甲苯磺酰胺环合、环醚开环、羟基活化、环合等4步反应以58%的收率合成了目标产物,相比已有合成方法,该合成路线以甲磺酰基(-OMs)离去基替代溴原子,提高了收率、简化了反应的操作和后处理,适合工业化生产。The 2-benzyl-6-tosyl-2,6-diazaspiro[3,3]heptane was synthesized by the reaction of cyzlization with p-toluenesulfonamide,ring opening of ether,activation of hydroxyl group and cycalization from pentaerythritol tribromide as raw material with 58%total yield.By using the methylsulfonyl group（-OMs）instead of Br,the modified synthetic route is privileged with higher yield,more simple operation and especially suitable for industrial production.

关 键 词：三溴新戊醇 2 6-二氮杂螺[3 3]庚烷 合成 

分 类 号：O062[理学]