前列地尔联合三磷酸胞苷二钠治疗军事噪声性耳聋的临床疗效观察  

Efficacy of Alprostadil Injection Combined with Cytidine Disodium Triphosphate Injection in Treatment of Military Noise-induced Hearing Loss

作　　者：姜静岩[1] 李小云[1] 尹晓飞[1] 庞秀玲[2] 

机构地区：[1]解放军251医院药剂科,河北张家口075000 [2]解放军251医院五官科,河北张家口075000

出　　处：《解放军药学学报》2017年第1期88-90,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的评价前列地尔联合三磷酸胞苷二钠治疗军事噪声性耳聋的疗效及安全性。方法将由军事噪声引发的78例耳聋患者随机分为两组,对照组给予糖皮质激素、B族维生素、高压氧等常规治疗;治疗组在常规治疗的基础上加用前列地尔联合三磷酸胞苷二钠治疗,疗程均为2周。结果对照组有效率为69.23%,治疗组有效率为89.74%,两组差异具有统计学意义(P<0.05)。全部病例治疗期间没有发生药品不良反应。结论在常规治疗的基础上加用前列地尔联合三磷酸胞苷二钠,对治疗军事噪声性耳聋科有明显疗效,值得临床推广应用。Objective To evaluate the efficacy and safety of alprostadil injection combined with cytidine disodium triphosphate injection in the treatment of military noise-induced hearing loss.Methods Seventy eight cases of military noise-induced hearing loss were selected and divided into two groups randomly. Cases in control group underwent routine treatment with glucocorticoid, vitamin B and hyperbaric oxygen, while cases in treatment group received alprostadil injection combined with cytidine disodium triphosphate injection additionally. The treatment lasted 2 weeks.Results The efficiency was 69.23% in control group, but was 89.74% in treatment group.The difference was of statistical significance（ P 〈0.05）.There was no obvious adverse reaction during treatment. Conclusion Conventional treatment combined with alprostadil injection combined and cytidine disodium triphosphate injection has a remarkable effect on military noise- induced hearing loss ,and it is worthy of popularization in clinic.

关 键 词：前列地尔 三磷酸胞苷二钠 军事噪声 耳聋 

分 类 号：R963.3[医药卫生—微生物与生化药学]