广州市越秀区居民甲、乙、丙病毒性肝炎血清学监测结果分析  

The seroepidemiological study of hepatitis A,B,C in Yuexiu District in Guangzhou

作　　者：刘淑勤[1] 湛柳华[1] 许斌[1] LIU Shuqin ZHAN Liuhua XU Bin(Guangzhou City Yuexiu District Center for Disease Control and Prevention, Guangdong S10055 , China)

机构地区：[1]广州市越秀区疾病预防控制中心,广东510055

出　　处：《医学动物防制》2017年第3期264-266,共3页Journal of Medical Pest Control

基　　金："十一五国家科技重大专项课题"基金资助项目(2009ZX10001-018)

摘　　要：目的为更好地了解广州市越秀区居民病毒性肝炎的感染状况,分析影响因素,为探讨社区居民肝炎防控综合措施提供科学依据。方法采用分层整群随机抽样的方法,于2010年在广州市越秀区随机抽取一定数量的住户,对住户中全部人口共3 511人现场采集血样并用自制问卷调查患病史及疫苗接种史等,使用酶联免疫法检测肝炎血清学标志。结果调查人群抗-HAVIgG、抗-HCVIgG、HBsAg、抗-HBs、抗-HBc阳性率分别为91.83%、0.74%、7.18%、61.75%、17.23%。抗-HBc阳性率在各年龄组间差异有统计学意义(χ2=60.090,P<0.001),呈随年龄增长而增长趋势。HAV易感率为8.17%,其中19~岁组人群最低,与另两组别差异有统计学意义(χ2=17.620,P<0.01)。HBV易感率为21.47%,1~8岁组人群最低,9~18岁组人群最高,差异有统计学意义(χ2=6.970,P<0.05)。HCV易感率为99.26%,各年龄组间差异无统计学意义(χ2=0.005,P>0.05)。存在各型重叠感染的情况,各组合间感染率差异有统计学意义(χ2=1 556.978,P<0.01)。结论人群甲肝抗体水平较高,丙肝较低,乙肝仍有一定的易感人群,提示要继续巩固国家免疫规划儿童甲肝和新生儿乙肝疫苗接种,探讨青少年乙肝疫苗加强免疫、重点人群乙肝疫苗接种的可行性及落实健康教育、管理传染源等肝炎社区综合防控措施。Objective To investigate the serological prevalence of viral hepatitis A, B, C among general population in Yuexiu District and to provide evidence for local prevention and control of hepatitis A, B, C. Methods We conducted a multi - stage random cluster sampling method in 2010, a face to face questionnaire survey and blood sampling were conducted in each sub- ject. Results Positive rate of anti - HAV IgG, anti - HCV lgG, HBsAg, anti - HBs, anti - HBc was 91.83%, 0. 74%, 7.18%, 61.75%, 17.23% , respectively. There is a significant difference in anti -HBc between each age group, positive rate of anti- HBc increased according to the increase of age（x2=60. 090, P 〈 0. 001 ）. Susceptible rate to hepatitis A virus was 8.17% , the group of 19 ~ years old was significantly lower than other groups（x2 = 17. 620, P 〈0. 01 ）. Susceptible rate to hep- atitis B virus was 21.47%, the group of 1 -8 years old was the lowest, and the group of 9 - 18 years old was the highest（x2 = 6. 970, P 〈 0.05 ）. Susceptible rate to hepatitis C virus was 99.26%, there was no significant difference among different age groups（x2 = 0. 005, P 〉 0. 05 ）. The superinfection of different type hepatitis was observed in the study population （x2 = 1 556. 978, P 〈 0. 01 ）. Conclusion Antibody level was relative high in hepatitis A, while low in hepatitis C. There were some suspects to hepatitis B virus. It＇ s important to carry on the EPI of hepatitis A and the hepatitis B vaccination in newborn. And it＇ s necessary to study the booster immunization in adolescent, hepatitis B vaccination in key population and so on.

关 键 词：肝炎 血清学监测 特征分析 

分 类 号：R512.6[医药卫生—内科学]