D-二聚体在评估下肢深静脉血栓形成溶栓效果中的价值  

The Value of D-dimer in Evaluation of Thrombolysis Effect of Lower Limb Deep Venous Thrombosis

作　　者：李俊涛[1] 潘扬[2] 姜庆[2] 袁平[2] 

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]贵州省人民医院血管外科,贵州贵阳550001

出　　处：《贵州医科大学学报》2017年第2期205-208,共4页Journal of Guizhou Medical University

摘　　要：目的:观察下肢深静脉血栓形成(DVT)患者在溶栓过程中D-二聚体(DD)的达峰速度,探讨DD的达峰速度与溶栓效果的关系。方法:41例DVT患者分为系统溶栓组和导管接触性溶栓组,观察两组患者的DD峰值、达峰速度及疗效,采用Pearson法分析DD达峰速度与血栓溶栓率及下肢消肿率的相关性。结果:两组都在溶栓治疗后的第2天DD达峰值,但导管接触性溶栓组DD峰值及达峰速度明显高于系统溶栓组,导管接触性溶栓组溶栓治疗显效率亦高于系统溶栓组(P<0.01);相关性分析显示,DD的达峰速度分别与静脉通畅、大小腿消肿率呈正相关(r=0.912、0.85、0.86,P<0.01)。结论:可通过监测DD的达峰速度简单评估溶栓效果,导管接触性溶栓临床疗效优于系统溶栓。Objective：To investigate correlation between DD maximum speed and thrombolytic effect by observing maximum speed of DD in lower limb DVT patients.Methods：41 patients were divided into system thrombolysis group（group A） and catheter-directed thrombolysis group（group B）; observing DD maximum value,speed and efficacy.Analyzing correlation among the speed to the peak of D-dimer and thrombolytic rate and limb swelling disappeared rate.Result：Both groups reached the DD peak two days after treatment,but groups B DD peak value and speed were obviously higher than group A,group B showed better treatment efficiency than group A（P〈0.01）; correlation analysis indicated that DD peak reaching speed was positively correlated with thrombolytic rate and lower limb swelling disappeared rate（r = 0.912、0.85、0.86,P〈0.01）.Conclusion：It is a probable way to evaluate the effect of thrombolysis by monitoring the speed to the peak of D-dimer and the clinical curative effect of catheter thrombolysis is better than that of the system.

关 键 词：静脉血栓形成 D-二聚体 溶栓 达峰速度 治疗效果 

分 类 号：R543.6[医药卫生—心血管疾病]