降低IVF-ET治疗中多胎妊娠的方法及效果分析  

TREATMENT AND ITS OUTCOMES IN REDUCING THE MULTIPLE PREGNANCY RATES IN IVF-ET

作　　者：李宜学[1] 吴剑华[1] 郭剑[1] 赵铭佳[1] 崔静[1] 王振荣[1] 

机构地区：[1]河北省唐山市妇幼保健院,063000

出　　处：《中国煤炭工业医学杂志》2017年第2期114-117,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省自然科学基金项目(编号:C2007000894)

摘　　要：目的对比囊胚培养结合单囊胚移植(eBC-SBT)与卵裂期双胚胎移植在体外受精-胚胎移植(IVF-ET)周期治疗中的临床效果。方法回顾性分析2014年5月—2016年4月在唐山市妇幼保健院生殖中心接受IVF-ET治疗的不孕患者1 272对,均为移植双胚胎具有高风险双胎妊娠可能性的患者,对其进行一对一充分沟通,根据患者意向分为卵裂期双胚胎移植组(A组)和单囊胚移植组(B组),分析二组间的临床妊娠率、种植率、多胎率等。结果单囊胚移植组的种植率高于卵裂期移植组(52.27%vs32.94%,P<0.05),临床妊娠率略降低(50.76%vs 55.95%,P>0.05),但单囊胚移植的多胎率明显降低(1.49%vs 23.58%,P<0.05),早产儿、低体重儿出生率降低(P<0.05),足月单胎活产率提高(P<0.05)。结论囊胚培养结合单囊胚移植相对与传统的卵裂期双胚胎移植能够得到较好的临床妊娠率,同时降低多胎率,能够改善临床妊娠结局。Objective To investigate the effects of elective blastocyst culture and single blastocyst transfer（eBC-SBT）on the reduction of multiple pregnancy rate.Methods From May 2014 to Apl 2016,1272 fresh cycles of assisted reproductive techniques were analyzed.Patients with high risk of multiple pregnancy were advised to receive eBC-SBT with the consent（group B）.Patients who refused to perform eBCSBT were transferred D3 cleavage embryos（group A）.The implantation rate,clinical pregnancy rate and multiple pregnancy rate were compared between the two groups.Results The implantation rate in group B was significantly increased when compared to group A（52.27% vs 32.94%,P〈0.05）.Though the clinical pregnancy rate（50.76% vs 55.95%,P〉0.05）slightly decreased in group B,but the multiple pregnancy rate（1.49% vs 23.58%,P〈0.05）,preterm delivery and low weight birth significantly decreased（P〈0.05）.Conclusions The strategy of eBC-SBT can effectively reduce the multiple pregnancy rate,and improve the outcome of pregnancy,but do not decrease the clinical pregnancy rate.

关 键 词：体外受精 囊胚 种植率 

分 类 号：R719.9[医药卫生—妇产科学]