Hedgehog信号通路临床研究进展  

Clinical Research Progress of Hedgehog Signaling Pathways

作　　者：孙婧[1] 菅天孜 王珂[1] 高蓓钧 菅向东[1] 

机构地区：[1]山东大学齐鲁医院急诊科中毒与职业病科,济南250012 [2]泰山医学院,山东泰安271016

出　　处：《医学综述》2017年第4期625-628,633,共5页Medical Recapitulate

基　　金：山东省重点研发计划项目(2015GSF118038);山东大学横向科研项目(11671405,11671423);山东省医药卫生科技发展项目(2014WS0150,3BJYB12)

摘　　要：Hedgehog通路是一条保守的信号通路,对胚胎发育起重要的调控作用,可促进上皮细胞向间质细胞的转化。Hedgehog基因编码一系列分泌蛋白,最初在果蝇调控胚胎过程中被发现,对胚胎发育过程中的细胞分化和增殖起重要作用。Hedgehog信号通路不恰当的激活可引起多种肿瘤及纤维化的发生。近年来,有关Hedgehog信号通路的研究取得了较大的进展,特别是在肿瘤的发病机制方面。针对Hedgehog信号通路中各靶点的治疗研究也为肿瘤治疗开辟了一条新的途径,具体疗效还需要进一步深入研究。The Hedgehog pathway is a conservative signaling pathway,playing an important regulatory role for embryonic development,which can promote the transformation of epithelial to mesenchymal cells. The Hedgehog gene encodes a series of secreted proteins,which were found in the regulation of Drosophila embryos,and plays an important role in cell differentiation and proliferation during embryonic development. The improper activation of Hedgehog signaling pathway can lead to the occurrence of a variety of tumors and fibrosis. In recent years,the studies of Hedgehog signaling pathways have made greater progress,especially in the pathogenesis of tumor. The study of each target of the Hedgehog signaling pathway also opens up a new way for tumor treatment,though the specific curative effect needs further in-depth study.

关 键 词：HEDGEHOG通路 发病机制 分子生物学 

分 类 号：R456.7[医药卫生—治疗学]