可逆加成断裂链转移法制备阿司匹林印迹材料及性能评价  

Reversible addition fragmentation chain transfer preparation and performance evaluation of aspirin imprinted material

作　　者：苏立强[1] 周磊[1] 韩爽[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,齐齐哈尔161006

出　　处：《分析试验室》2017年第2期168-171,共4页Chinese Journal of Analysis Laboratory

基　　金：环境保护部项目(201209048);黑龙江省教育厅项目(12531757)资助

摘　　要：以埃洛石为载体,阿司匹林为药物模板,丙烯酰胺为功能单体,二甲基乙二醇丙烯酸酯为交联剂,采用表面可逆加成断裂链转移法制备了特异性吸附良好的药物印迹材料.利用热重(TG)对其结构进行表征。在埃洛石表面包覆了均匀的印迹层,与化学组成相同的非印迹材料相比,印迹材料热稳定性好;通过Langmuir和Freundlich理论模型结合吸附实验、选择性实验以及再生实验评价聚合物性能,印迹聚合物表面存在非均一性识别位点,吸附过程属于多相吸附,相较于其他三种药物模板结构类似物,印迹聚合物对阿司匹林具有高度选择识别性,且经7次循环使用后,依旧表现较高吸附性.The molecularly imprinted material was prepared using the surface molecular imprinting technique with reversible addition fragmentation chain transfer with halloysite nanotubes as carrier,aspirin as template molecule,acrylamide as functional monomer,and edma as crosslinker.The imprinted material was characterized by thermal gravimetric（TG）.The results showed that a homogeneous imprinted polymer layer was successfully coated onto the surface of modified halloysite nanotubes.The imprinted material exhibited excellent thermal stability compared with the non imprinted material with similar chemical components.The performance of molecularly imprinted material was evaluated by adsorption experiment with Langmuir model analysis and Freundlich model analysis,selective adsorption,and regeneration experiment.The results showed that the recognition sites on the surface of imprinted material were non uniform,and the adsorption process was multilayer adsorption.In contrast to the other analogues, imprinted material showed outstanding selective recognition ability for aspirin.Moreover,after seven cycles,the imprinted material was still favorable for reuse.

关 键 词：分子印迹 表面可逆加成断裂链转移法 埃洛石纳米管 阿司匹林 吸附特性 

分 类 号：R917[医药卫生—药物分析学]