骨性关节炎所致慢性持续性疼痛的发病机制  

The pathogenesis of osteoarthritis-induced chronic persistent pain

作　　者：张希[1] 刘萍[2] 

机构地区：[1]山东大学附属省立医院药剂科,山东济南250021 [2]山东大学附属省立医院乳腺甲状腺外科,山东济南250021

出　　处：《中国骨质疏松杂志》2017年第2期248-255,共8页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金资助项目(81300964);中国博士后科学基金资助项目(2014T70648);中国博士后科学基金面上资助项目(2013M531611);山东省中医药科技发展计划项目(2013-190)

摘　　要：在世界范围内,骨关节炎(osteoarthritis,OA)已成为引起肌肉骨骼疼痛和功能残疾的主要病因。尽管临床上已使用多种保守或介入治疗方法,但是仍不能有效控制OA所致的疼痛。各种原因引起的慢性疼痛特别是神经病理性疼痛是最具挑战的临床医疗和公众健康问题,给患者及其家庭乃至社会带来沉重的精神和经济负担。慢性疼痛治疗手段繁多但疗效却并不满意,究其原因主要是对慢性疼痛的发生发展机制认识尚不足,且已知的科研成果尚未转化为临床治疗手段。本文旨在综述OA所致慢性疼痛的潜在病理生理机制,以期探讨新的有效控制OA痛的作用靶点,对新药研发及新的治疗策略提供思路。Osteoarthritis（OA） is the leading cause of musculoskeletal pain and functional disability worldwide,affecting a growing number of individuals in the society.Despite various conservative and interventional treatment approaches,the overall management of the condition is still problematic,and pain,the major clinical problem of the disease,remains sub-optimally controlled.Due to a variety of causes,chronic neuropathic pain is the most challenging clinical medicine and public health problem for patients and their families,which at the same time brings the society a heavy psychological and economic burden.There are various treatments for chronic pain but none has satisfying curative effects,which is primarily due to the inadequate understanding towards the development mechanism of chronic pain,and findings of scientific research are yet to be translated into clinical treatment.The objectives of this review are to present the pathophysiologic mechanisms underlying the complexity of pain in OA and to discuss the challenges for new treatment strategies aimed to translate experimental findings into daily clinical practice.

关 键 词：骨性关节炎 慢性神经病理性疼痛 炎症性疼痛 

分 类 号：R684[医药卫生—骨科学]