阿司匹林治疗绝经后骨质疏松症的实验研究进展  

Experimental research progress in the treatment of postmenopausal osteoporosis with aspirin

作　　者：苏菲[1] 桑宏勋[1] 

机构地区：[1]第四军医大学西京医院骨科,陕西西安710032

出　　处：《中国骨质疏松杂志》2017年第2期267-271,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81270959)

摘　　要：综述阿司匹林治疗绝经后骨质疏松的实验研究进展,简要介绍阿司匹林的特性及在临床上的应用,以及阿司匹林治疗骨质疏松的机制,为治疗骨质疏松提供一种新的方法。以在体实验和离体实验作为文献的基本分类标准,进一步以各项实验室检测指标作为细化分类,广泛查阅近年来国内外有关阿司匹林治疗绝经后骨质疏松实验的相关文献,并综合分析。在体实验方面,分别从骨密度、骨组织形态学、骨生物力学、骨代谢生化指标等方面进行阐述;离体实验方面,整理阿司匹林治疗绝经后骨质疏松相关机制的信号通路、细胞因子表达及相关基因表达的实验研究进展。在此基础上做出总结,指出目前研究尚存在的问题,主要包括阿司匹林治疗绝经后骨质疏松症作用机理未完全阐明,以及相关流行病学研究的匮乏;提出下一步探究的思路,以期为相关研究者提供借鉴与参考。The latest experimental research progress in the treatment of osteoporosis with aspirin is reviewed.The characteristics of aspirin,its application in clinic,and the mechanism of aspirin acting in the treatment of osteoporosis are introduced,in order to provide a new method for osteoporosis treatment.On the basis of experiments in vivo and in vitro,with sub-classified as the laboratory test indexes,national and international literatures on treatment of postmenopausal osteoporosis with aspirin in recent years are extensively reviewed and analyzed.The bone mineral density,bone histomorphometry,bone biomechanics,and bone metabolism are summarized,respectively,from in vivo experiments.From in vitro experiments,experimental research progress of aspirin in the treatment of postmenopausal osteoporosis related mechanism of signaling pathways,cytokines,and related gene expression is summarized.Based on these,the problems of current research are pointed out.The problems mainly include the unknown mechanism of aspirin in the treatment of postmenopausal osteoporosis,and a lack of relevant epidemiological studies.At last,the research ideas of next step are proposed,in order to offer the reference for related researchers.

关 键 词：阿司匹林 绝经后骨质疏松 实验研究 

分 类 号：R681[医药卫生—骨科学]