嗜酸粒细胞活化趋化因子与CCR3在慢性自发性荨麻疹患者血清中的表达  

Expression of eotaxin and CCR3 on peripheral blood in patients with chronic spontaneous urticaria

作　　者：杨艳[1] 李嘉彦[1] 李薇[1] 周欣[1] 熊斯颖[1] 张三泉[1] 刘玉梅[1] 朱慧兰[1] 

机构地区：[1]广州市皮肤病防治所,广东广州510095

出　　处：《皮肤性病诊疗学杂志》2017年第1期14-16,共3页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:探讨嗜酸粒细胞活化趋化因子(eotaxin)与其相应受体CCR3的表达在慢性自发性荨麻疹发病中的作用。方法:采用酶联免疫吸附试验检测45例慢性自发性荨麻疹患者及30例正常人血清中eotaxin水平;同时用流式细胞仪分析外周血中CCR3的表达。结果:与正常对照组相比,患者组血清中eotaxin明显升高[(198.63±46.35)pg/m L vs(104.55±38.45)pg/m L];外周血CCR3表达水平显著增加[(38.24±6.87)%vs(20.37±5.40)%],差异均有统计学意义(t值分别为4.25、11.98,P值均<0.05)。结论:具有生物活性趋化因子及其受体介导的嗜酸性粒细胞的聚集、激活后释放的炎性介质在慢性自发性荨麻疹发病中起着重要作用。Objective：To study the role of serum eotaxin and its receptors CCR3 in the patho- genesis of chronic spontaneous urticaria. Methods：Serum level of eotaxin was detected by enzymlinked immunosorbent assay（ELISA） in 45 patients with chronic spontaneous urticaria and 30 normal controls. Meanwhile, CCR3 on peripheral blood monocytes was analyzed by flow cytometry. Results ： Serum level of eotaxin was significantly higher（ P 〈 0.05 ） in patients with chronic spontaneous urticaria. The expression of CCR3 on peripheral blood monocytes was increased （P 〈 0.05 ） in peripheral blood of the patients in comparison with those of the healthy controls. Conclusion： Both eotaxin with biological activity and its receptor may lead to the recruitmet and activation of cosiphils, which appear to play an important role in by releasing of mediator of inflammation.

关 键 词：荨麻疹 EOTAXIN CCR3 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]