Drug-Drug Interaction Studies of Levocetirizine with Atenolol  

作　　者：Shafaque Mehboob Muhammad Azhar Mughal Khalid Aftab MoonaMehboob Khan Najma Sultana Syed Arayne 

机构地区：[1]Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi 75510, Pakistan [2]Department of Pharmacology & Therapeutics, Jinnah Sindh Medical University, Karaehi 75510, Pakistan [3]Department of Pharmacology & Therapeutics, Islam Medical & Dental College, Sialkot 51311, Pakistan [4]Department of Pharmaceutical Chemistry, Dow University of Health Sciences, Karachi 74200, Pakistan [5]Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan

出　　处：《Journal of Pharmacy and Pharmacology》2017年第3期118-124,共7页药剂与药理学（英文版）

摘　　要：The objective of the study was to evaluate the drug-drug interaction studies of levoceterizine with atenolol. Calibration curve studies of working standard solutions of levocetirizine and atenolol （0.01-0.1 mmol） were scanned. Maxima appeared at 231 nm for levocetirizine and 224 nm for atenolol. The calibration curve obeyed Beer Lambert＇s Law. Lone availabilities of both the drugs were studied in pH 1, pH 4, pH 7.4 and pH 9 at 37℃ on B.P. （British Pharmacopoeia） dissolution apparatus. To study the drug-drug interaction of levocetirizine （5 mg tablet） and atenolol （100 mg tablet）, both the drugs were introduced to the dissolution apparatus in simulated gastric juice （pH 1）, pH 4, pH 7.4 and pH 9 at 37℃ at zero time and measured the absorbance maxima of both the drugs at the corresponding wavelength. Graphs were plotted for availability percentage （%） of drug versus time at each set of experiment. The availability percentage （%） of levocetirizine in the buffers of pH simulated to gastric pH 4, pH 7.4 and pH 9 in the presence of atenolol was 436.78%, 376.90%, 436.78% and 436.78%, respectively, but the availability of atenolol was increased up to 214.80%, 212.96%, 214.93% and 231.51% in simulated to gastric pH and in the buffers ofpH 4, pH 7.4 and pH 9, respectively. On the basis of these studies, it is concluded that levocetirizine forms a charge-complex with atenolol; therefore, co-administration of these drugs should be avoided.

关 键 词：LEVOCETIRIZINE ATENOLOL drug-drug interactions absorbance maxima. 

分 类 号：X703[环境科学与工程—环境工程] S859.796[农业科学—临床兽医学]