海南省新诊断2型糖尿病人群血清25羟维生素D水平与各代谢指标的相关性研究  

Correlations between 25-hydroxy-vitamin D and metabolic parameters in newly diagnosed type 2 diabetes in Hainan province

作　　者：云川[1] 刘佳林[1] 陈小盼[2] 黄干[1] 彭健[1] 向宇飞[1] YUN Chuan LIU Jia-lin CHEN Xiao-pan et al(Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Ministry of Education ＆ Central South University, National Clinical Research Center for Metabolic Diabetes, Changsha 410011 ,China)

机构地区：[1]中南大学湘雅二医院代谢内分泌科、糖尿病免疫学教育部重点实验室、国家代谢性疾病临床医学研究中心,长沙410011 [2]海南医学院第一附属医院内分泌科

出　　处：《中国糖尿病杂志》2017年第2期125-130,共6页Chinese Journal of Diabetes

基　　金：国家自然科学基金青年基金(81400817);欧洲糖尿病基金项目(EFSD-CDS fellowship);中南大学升华育英人才计划

摘　　要：目的观察海南省新诊断T2DM患者的25羟维生素D[25(OH)D]水平,并探讨25(OH)D与各代谢指标的相关性。方法收集海南省102例新诊断T2DM患者及100名NGT人群的资料。测定FPG、TC、TG、LDL-C、HDL-C、钙(Ca)、磷(P)及血清25(OH)D水平。结果 T2DM组BMI、WC、WHR、SBP、DBP、FPG、TC、TG、LDL-C、Ca高于NGT组(P<0.05),HDL-C及25(OH)D低于NGT组(P<0.05或P<0.01)。相关分析显示,所有受试者25(OH)D水平与HDL-C呈正相关(r=0.149,P<0.05),与WC、WHR、FPG、TC、TG、Ca呈负相关(r=-0.170、-0.201、-0.257、-0.266、-0.431、0.211,P<0.05)。T2DM组25(OH)D水平与TC、TG呈负相关(r=-0.273、-0.483,P<0.05)。NGT组25(OH)D水平与TG呈负相关(r=-0.401,P<0.05)。Logistic回归分析显示,低VitD水平(LD)组患糖尿病风险高于高VitD(HD)组(OR:6.983,P<0.05);中VitD水平(MD)组腹型肥胖风险高于HD水平组(OR:2.271,P<0.05);LD及MD水平组TG增高风险高于HD水平组(OR:5.410、2.964,P<0.05);LD水平组HDL-C降低及血压升高的风险高于HD水平组(OR:3.441、5.690,P<0.05)。结论海南省新诊断T2DM患者VitD水平较NGT人群低;VitD缺乏可能是T2DM及MS发病的危险因素。Objective To investigate the association between 25-hydroxy-vitamin D[25（OH）D]and the metabolic indices in newly diagnosed type 2 diabetes（T2DM） in Hainan province.Methods Clinical data were collected from 102 newly diagnosed T2 DM and 100 normal glucose tolerance controls in Hainan province.Fasting plasma glucose（FPG）,total cholesterol（TO,triglyceride（TG）.low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C）,serum calcium（Ca）,serum phosphorus（P） and serum 25（OH）D were detected.Results（1） Body mass index（BMI）,waist circumference（WC）,waist-to-hip ratio（WHR）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）.FPG.TC,TG,LDL-C and Ca were higher in diabetic subjects than controls（P〈0.05）;while HDL-C is lower（P〈0.05）.（2） Serum 25（OH）D levels in diabetic subjects were significantly lower than controls[（25.30±7.278） vs（28.72 ± 7.196） ng/ml,P〈0.01].（3） The 25（OH）D levels were positively correlated with HDL-C（r=0.149,P〈0.05）,and negatively correlated with WC,WHR,FPG,TC,TGand Ca^（2＋）（r=-0.170,-0.201,-0.257,-0.266,-0.431,-0.211,respectively,P〈0.05） in all subjects.The 25（OH）D levels and TC,TG showed a negative correlation（r=- 0.273,- 0.483,P〈0.05） in diabetic subjects.The 25（OH）D levels was negatively correlated with TG（r=- 0.401,P〈0.05） in controls.（4） Logistic regression analysis indicated that low vitamin D group（LD） had increased risk of diabetes compared with high vitamin D group（HD）（QR：6.983,P〈0.05）;the risk of abdominal obesity in mid vitamin D group（MD） was higher than HD（OP：2.271,P〈0.05）;the risk of elevated TG in LD and MD was higher than HD（QR：5.410,2.964,P〈0.05）;the risk of elevated blood pressure and decreased HDL-C in LD was higher than HD（OR：3.441,5.690,P〈0.05）.Conclusion Vitamin D levels in newly diagnosed T2 DM are lower than those of normal glucose tolerance controls in Hainan provi

关 键 词：糖尿病 2型 25羟维生素D 

分 类 号：R587.1[医药卫生—内分泌]