男性高尿酸血症患者成纤维细胞因子21与血尿酸和胰岛素抵抗的关系  

Relationship of serum fibroblast growth factor-21 with uric acid and insulin resistance in male patients with hyperuricemia

作　　者：赵江波[1] 杨玲[1] 尹卫[1] 陈霞[1] 王蓓[2] 施良[3] 丁伟[4] ZHAO J iang-bo YANG Ling YIN Wei et al(Department of Endocrinology and Metabolism, The Affiliated Hospital to J iangsu University, Zhenjiang 212001 , China)

机构地区：[1]江苏大学附属医院内分泌代谢科,镇江212001 [2]江苏大学附属医院检验科,镇江212001 [3]江苏大学附属医院核医学科,镇江212001 [4]江苏大学附属医院对外服务部,镇江212001

出　　处：《中国糖尿病杂志》2017年第2期140-143,共4页Chinese Journal of Diabetes

基　　金：镇江市社会发展项目(SH2015042)

摘　　要：目的探讨男性高尿酸血症(HUA)患者中成纤维细胞因子21(FGF21)水平与血尿酸(SUA)和IR的关系。方法在体检人群中选择男性高尿酸血症患者(HUA组)和健康者(NC组)各85名,HUA组以BMI水平分为HUA-高BMI亚组(n=41)及HUA-正常BMI亚组(n=44),分别检测FGF21、Hb A_1 c、BP、血脂、HOMA-IR等参数。结果 HUA组FGF21高于NC组[(1.99±0.96)vs(1.73±0.50)ng/ml,P<0.05];HUA-高BMI亚组FGF21水平高于HUA-正常BMI亚组[(2.04±3.61)vs(1.84±2.15)ng/ml,P<0.05];FGF21水平与BMI、WHR、TG、ln(HOMA-IR)、FIns、SUA呈正相关(r=0.456、0.355、0.231、0.257、0.220、0.222,P<0.05或P<0.01);多元线性逐步回归分析显示,WHR、SUA、ln(HOMA-IR)、TG是血清FGF21独立影响因素(P<0.05)。结论 FGF21在男性HUA患者中升高,且与SUA、1n(HOMA-IR)、BMI、WHR及脂代谢相关,其可能参与男性HUA患者的病理生理过程。Objective To investigate the relationship of serum fibroblast growth factor-21（FGF21）with uric acid（SUA） and insulin resistance（IR） in male patients with hyperuricemia.Methods 85 male patients with hyperuricemia（HUA） were divided into two subgroups according to BMI：HUA-high BMI subgroup（n=41） and HUA-normal BMI subgroup（n=44）.85 healthy volunteers served as normal controls（NC group）.FGF21,HbA1c,blood pressure,blood lipid and ln（HOMA-IR）were measured.Results Serum FGF21 level in HUA group was higher than those in NC group[（1.99±0.96）vs（1.73±0.50）ng/ml,P〈0.05].HUA-high BMI subgroup had higher FGF21 than HUA-normal BMI subgroup[（2.04±3.61）vs（1.84±2.15）ng/ml,P〈0.05].The FGF21 level was positively correlated with BMI,WHR,TG,ln（HOMA-IR）,FIns and SUA（r=0.456,0.355,0.231,0.257,0.220,0.222;P〈0.05 or P〈0.01）.Multiple linear stepwise regression analysis showed that WHR,SUA,ln（HOMA-IR）and TG were independent factors of FGF21（P〈0.05）.Conclusion FGF21 is correlated with SUA,ln（HOMA-IR）,BMI,WHR and lipid level.Elevated FGF21 may contribute to the pathophysiology of hyperuricemia in male patients with hyperuricemia.

关 键 词：高尿酸血症 男性 成纤维细胞因子21 血尿酸 胰岛素抵抗 

分 类 号：R589.7[医药卫生—内分泌]