中枢神经系统受累肺炎支原体感染患儿的疗效分析  

Therapeutic effect of central nervous system involvement in children with mycoplasma pneumoniae infection

作　　者：张志英[1] 张小宁[1] 韩淑娟[1] 常会娟[1] 靳秀红[1] 

机构地区：[1]郑州市儿童医院呼吸内科,450000

出　　处：《国际医药卫生导报》2017年第6期872-874,共3页International Medicine and Health Guidance News

摘　　要：目的对联用阿奇霉素和丙种球蛋白治疗小儿肺炎支原体感染合并中枢神经系统受累的临床效果进行系统分析。方法选取2015年3月至2016年3月本院儿科收治的63例肺炎支原体感染合并中枢神经系统受累患儿纳入此次研究中，依照入院时间不同随机分成联合组（33例）和常规组（30例）；常规组单一应用阿奇霉素治疗，联合组同时加用丙种球蛋白，治疗完成后，对两组临床疗效进行比较分析。结果通过治疗，联合组临床总有效率为97．0％，常规组为73．3％，两组比较差异有统计意义（P〈0．05）；且联合组患儿症状平均消失时间、住院时间均要短于常规组，差异有统计意义（P〈0．05）；在用药治疗中，两组均未出现明显不良反应。结论在小儿肺炎支原体感染合并中枢神经系统受累治疗中，采取阿奇霉素联用丙种球蛋白治疗的效果更为确切，可有效改善患儿症状，且安全性良好，临床应用意义重大。Objective To analyze the clinical effect of azithromycin combined with gamma globulin in the treatment of central nervous system involvement in children with mycoplasma pneumoniae infection. Methods From March 2015 to March 2016, 63 children with mycoplasma pneumoniae infection and central nervous system involvement in our hospital were enrolled in this study, and randomly divided into combined group （33 cases） and control group （30 cases） according to the different admission time. Control group was treated with azithromycin only, combined group was treated with azithromycin and gamma globulin. After treatment, compared the clinical efficacy of the two groups. Results The total effective rate of combined group was 97.0%, that of control group was 73.3%, with statistically significant difference between two groups （P〈0.05）. The average symptom disappearance time and the length of stay of combined group were significantly shorter than those of control group, with statistically significant differences between two groups （P〈0.05）. There were no obvious adverse reactions in two groups during the treatment. Conclusion In the treatment of children with central nervous system involvement and mycoplasma pneumoniae infection, azithromycin combined with gamma globulin has more precise treatment effect, can effectively improve the symptoms, with good safety, with clinical significance.

关 键 词：阿奇霉素 丙种球蛋白 肺炎支原体 中枢神经系统受累 

分 类 号：R725.6[医药卫生—儿科]