TRF,Cys-C,RBP和Hcy联合检测对糖尿病肾病的早期诊断价值  

Value of Combined Detection of Urine TRF,Serum Cystatin C(Cys-c) Retinol Binding Protein(RBP) and Homocysteine(Hcy) in Diagnosis of Early Diabetic Nephropathy

作　　者：李卉[1] Li Hui(Affiliated Hospital of Beihua University, Jilin 132011, China)

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2017年第2期224-227,共4页Journal of Beihua University（Natural Science）

基　　金：吉林省卫生计生委科研计划项目(2014Z083);吉林市科技发展计划项目(201536046)

摘　　要：目的探讨联合检测尿转铁蛋白(TRF)、血清胱抑素C(Cys-C)、视黄醇结合蛋白(RBP)和同型半胱氨酸(Hcy)对糖尿病肾病(DN)的早期诊断价值.方法依据糖尿病诊断标准和24 h尿白蛋白排泄率(UAER)的检查结果,将早期糖尿病肾病(DN)微量蛋白尿组患者40例(30 mg/24 h≤UAER≤300 mg/24 h)作为观察组A组,临床蛋白尿组患者40例(UAER>300 mg/24 h)作为观察组B组,同期健康体检者40例作为对照组.比较3组TRF,Cys-C,RBP和Hcy水平.结果 1)TRF,Cys-C,RBP和Hcy在A,B组中明显升高,与正常对照组比较,差异具有统计学意义(P<0.05).2)TRF,Cys-C,RBP和Hcy在B组中明显升高,与A组和对照组比较,差异具有统计学意义(P<0.05).结论 TRF,Cys-C,RBP和Hcy联合检测对于早期糖尿病肾病(DN)的诊断具有重要意义.Objective To discuss the value of combined detection of urine TRF,Serum Cystatin C,Retinol Binding Protein（RBP） and Hcy in Diagnosis of early diabetic nephropathy.Method Diagnostic criteria for diabetes and 24 h urinary albumin excretion rate（UAER） were examined.40 patients with early diabetic nephropathy（DN）（30 mg/24 h ≤ UAER ≤300 mg/24 h） as group A,40 patients with clinical albuminuria group（UAER300 mg/24 h） as group B,physical examination is 40 cases as normal control group.The urinary TRF,Cys-C,RBP and Hcy level of three groups were compared.Results 1） Urinary TRF,Cys-C,RBP and Hcy level in the early DN group and the clinical DN group increased significantly,compared with normal control group.The difference was statistically significant（P〈0.05）.2） Urinary transferrin Cys-C,serum retinol binding protein and homocysteine in group B increased significantly,compared with group A and the control group,the difference was statistically significant（P〈0.05）.Conclusion Urinary TRF,Cys-C,RBP and Hcy combined detection for the diagnosis of early diabetic nephropathy（DN） has important significance.

关 键 词：尿转铁蛋白 血清胱抑素C 视黄醇结合蛋白 同型半胱氨酸 糖尿病肾病早期 

分 类 号：R587.2[医药卫生—内分泌]